Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 545486..546003 Replicon chromosome
Accession NZ_CP049206
Organism Agrobacterium rubi strain W2/73

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1B9U2M4
Locus tag G6M88_RS02690 Protein ID WP_065697954.1
Coordinates 545486..545755 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1B9U2N3
Locus tag G6M88_RS02695 Protein ID WP_065697953.1
Coordinates 545752..546003 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6M88_RS02670 (G6M88_02670) 541517..542500 - 984 WP_065697958.1 ABC transporter substrate-binding protein -
G6M88_RS02675 (G6M88_02675) 542582..543415 - 834 WP_065697957.1 PhzF family phenazine biosynthesis protein -
G6M88_RS02680 (G6M88_02680) 543555..544799 - 1245 WP_065697956.1 PLP-dependent aminotransferase family protein -
G6M88_RS02685 (G6M88_02685) 545040..545495 + 456 WP_065697955.1 RbsD/FucU family protein -
G6M88_RS02690 (G6M88_02690) 545486..545755 - 270 WP_065697954.1 Txe/YoeB family addiction module toxin Toxin
G6M88_RS02695 (G6M88_02695) 545752..546003 - 252 WP_065697953.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G6M88_RS02700 (G6M88_02700) 546292..547311 - 1020 WP_045228891.1 ketol-acid reductoisomerase -
G6M88_RS02705 (G6M88_02705) 547356..548009 - 654 WP_065698258.1 TetR/AcrR family transcriptional regulator -
G6M88_RS02710 (G6M88_02710) 548159..548566 - 408 WP_065697952.1 helix-turn-helix domain-containing protein -
G6M88_RS02715 (G6M88_02715) 548701..549588 + 888 WP_141680554.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-72)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10552.08 Da        Isoelectric Point: 9.5727

>T151046 WP_065697954.1 NZ_CP049206:c545755-545486 [Agrobacterium rubi]
MKLVWTSNAWDDYEFWQKTDMRMVEKINEIIKNAKRTPFAGLGKPEPLKGDLSGFWSRRITGEHRFVYRVAGSGDEQRLE
ILQCRFHYA

Download         Length: 270 bp

>T151046 NZ_CP065178:c3460471-3460055 [Pectobacterium quasiaquaticum]
GTGAGTCGGTTGTTCATGCTGGATACTAATATCTGTTCCTTCATTATGCGTGAACACCCTGCGGCGGTGATTGAAAAGTT
GCAGCAGTGCACGTTGCGACGTGACCGGATTGTGGTCTCTGCTATCACTTACGCCGAAATGCGCTTTGGGGCGGTTGGTA
AAAAAGCCTCGCCGCGCCATATGCCACTGGTTGATGCTTTCTGCCGTCGGCTCGATGCGGTGCTGCCTTGGGATAGCGCT
GCGGTAGACGCCACCACGAAAATCAAAATCGCGTTAGCCGCAGCAGGCACGCCTATTGGCCCGAATGATACAGCTATAGC
TGGTCATGCCATCAGTGCTAAGGCCATATTGGTTACCAATAATCTGAGAGAATTTGAGCGAGTAGCGGGGCTGACGTTGG
AAGATTGGGCTAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9546.67 Da        Isoelectric Point: 4.5158

>AT151046 WP_065697953.1 NZ_CP049206:c546003-545752 [Agrobacterium rubi]
MVNVRFTEFRQNFATHFDTVLESRAPLLVTRQGKEAVVVIAEGEFESMQETLHLLSTPANTNRLRESLEQLRDGETIERD
PTE

Download         Length: 252 bp

>AT151046 NZ_CP065178:c3460695-3460468 [Pectobacterium quasiaquaticum]
ATGCGTATTGTTTCGGTATTTAAAAACGGTAACAACCGTGCCATTCGTTTGCCACGTGATATGGACTTTGAAGGCGTTAA
CGAACTGGAGATTGTGCGTGAGGGAGATACCATCATGTTGCGTCCGGTCAAACCCAATTGGCAGTCGTTTTTGCAAGAAG
ATCGCGCTGACGCTGACTTTATGACAGAACGCCAGGATGTGGTCGAAGAGGGGAGATTCGAACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B9U2M4

Antitoxin

Source ID Structure
AlphaFold DB A0A1B9U2N3

References