Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4160446..4161048 Replicon chromosome
Accession NZ_CP049197
Organism Escherichia coli strain E597

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag G6Z98_RS19715 Protein ID WP_000897305.1
Coordinates 4160737..4161048 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G6Z98_RS19710 Protein ID WP_000356395.1
Coordinates 4160446..4160736 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6Z98_RS19680 4156069..4156971 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
G6Z98_RS19685 4156968..4157603 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
G6Z98_RS19690 4157600..4158529 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
G6Z98_RS19695 4158711..4158953 - 243 WP_021523315.1 hypothetical protein -
G6Z98_RS19700 4159172..4159390 - 219 WP_001295676.1 ribbon-helix-helix domain-containing protein -
G6Z98_RS19705 4159809..4160087 - 279 WP_001306650.1 hypothetical protein -
G6Z98_RS19710 4160446..4160736 - 291 WP_000356395.1 helix-turn-helix domain-containing protein Antitoxin
G6Z98_RS19715 4160737..4161048 - 312 WP_000897305.1 hypothetical protein Toxin
G6Z98_RS19720 4161277..4162185 + 909 WP_001306651.1 alpha/beta hydrolase -
G6Z98_RS19725 4162354..4164168 - 1815 WP_020233236.1 hypothetical protein -
G6Z98_RS19730 4164584..4165525 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
G6Z98_RS19735 4165570..4166007 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T150951 WP_000897305.1 NZ_CP049197:c4161048-4160737 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T150951 NZ_CP065152:c3531299-3531192 [Escherichia coli O150:H6]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT150951 WP_000356395.1 NZ_CP049197:c4160736-4160446 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT150951 NZ_CP065152:3531347-3531413 [Escherichia coli O150:H6]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References