Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1155553..1156055 Replicon chromosome
Accession NZ_CP049197
Organism Escherichia coli strain E597

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag G6Z98_RS05345 Protein ID WP_000767829.1
Coordinates 1155801..1156055 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag G6Z98_RS05340 Protein ID WP_001259255.1
Coordinates 1155553..1155804 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6Z98_RS05315 1150731..1151798 - 1068 WP_000080136.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
G6Z98_RS05320 1151798..1152868 - 1071 WP_000108937.1 histidinol-phosphate transaminase -
G6Z98_RS05325 1152865..1154169 - 1305 WP_021523144.1 histidinol dehydrogenase -
G6Z98_RS05330 1154175..1155074 - 900 WP_021523143.1 ATP phosphoribosyltransferase -
G6Z98_RS05335 1155220..1155270 - 51 WP_001364200.1 his operon leader peptide -
G6Z98_RS05340 1155553..1155804 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
G6Z98_RS05345 1155801..1156055 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
G6Z98_RS05350 1156138..1156962 + 825 WP_000754758.1 SDR family oxidoreductase -
G6Z98_RS05355 1157008..1157937 + 930 WP_023154044.1 LysR family transcriptional regulator -
G6Z98_RS05360 1158152..1158214 + 63 WP_010723108.1 membrane protein YoeI -
G6Z98_RS05365 1158204..1159562 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
G6Z98_RS05370 1159741..1160799 + 1059 WP_000492324.1 transport protein YeeE -
G6Z98_RS05375 1160813..1161040 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T150927 WP_000767829.1 NZ_CP049197:1155801-1156055 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T150927 NZ_CP065148:c108213-106870 [Proteus mirabilis]
ATGAAAGCTCAAATACTATCTGTTGCTATGAATGGTGATTTGGTTGGTAAACTAACCAAAAATACTGATGGTGGGATGTC
ATTTCAATACGCAGAAGAATGGTTGGCTGAACCAGGAGCGCGGGCAATCTCATTATCACTTCCTTTGCAAAAGGGGCGCA
TAATCGGTAGCGCAGTTTACAATTTCTTCAGCAACCTTTTACCTGATTCTGAGGCAATTATTGATAGAATGCAGATTCGT
TTTAAGGTAAAAACAAACCATCCTTTTGATCTGCTAGCCGCTGTAGGTCGTGACTGTGTTGGCGCAATCCAATTATATTC
TCCTGATACTGAAATTCCATCGGTGATGGAAACCCATGCTGAACCTTTAAATGAAAATCAAATCGAAGAGCTTTTAGACG
GTTATCAAACCGCCCCCCTTGGAATGTCCGAGGATGTAGACTTTCGGATCTCCCTTGCAGGGGCTCAAGAGAAAACAGCA
TTACTTTGGTATCAAGACTGTTGGCAGCGACCACAAGGCAGTACCCCGACAAGTCATATTTTCAAATTGCCCATAGGTCT
GATTGAACACCATAATATTGATCTGCGCGAAAGCTGTGAAAACGAATGGCTATGCTTGTGTATAGCAAGAGAATTTGGAT
TTCCAGTCACCAACGCTGAATTGGCAATATTCGGTCAGAAAAAGGTACTGATCGTAGAGCGTTTTGACCGAAAATGGTCC
TCATCTGGGAACTGGCTGTTGCGCCTTCCCCAAGAGGATTGCTGTCAGGCTTTGAGCGTTGCCCCTGCATTAAAATATGA
ATCTGATGGTGGTCCAGGTATTGAATCTATCATGACGTTGCTTTTGGGCTCACAAAAAGCCATCGACGATAGAGAAATGT
TTTTTAAATCACAAATTCTGTTCTGGATGCTGGCCGCTATAGATGGGCATGGGAAAAACTTTTCCATCTTCATTGAATCT
GGAACATCTTTTCGTTTAACGCCCTTGTATGATGTTATGTCTGCTTTCCCAATTTTTGAAGCACGAGGAATTGAGATAAA
AAAGGCCAAAATGGCTATGGCATTACAAGGAAAAAACAGACAATACAATTTTTCCATGATACAACCTCGTCATTTTATCT
CTACCGCTACAAAGGTCGGGTTTCCAACAAAAACCGCAATGGAGCTAATGGTTGATATGGCCGAAAAGACTGATGCAGTT
ATAGCTACCGTATCATCTCAACTACCTGCGGACTTTCCTGAGCATATCAGTAACGCCATATTTAGTGGGTTATCAATACA
AGCCGATAAGATTAAAAGATTGTCTTCAGGAACGAGCTCACAAAATATGATGGTTTCGAATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT150927 WP_001259255.1 NZ_CP049197:1155553-1155804 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT150927 NZ_CP065148:c108468-108217 [Proteus mirabilis]
ATGAAAATTACAACGCCATCAATGTTAGCCGCTGCAATACATGACTTGCGCAAACAAAGTAAATTAACCCAAGCTCAAAC
GGCTGAACAAGTCGGTCTCAGGCAAGCAACTGTCTCTGAATTTGAGAACAACCCAGAATCAACAAAACTCGAAACGCTTT
TCAAAATCCTTGCCTCTTTGGAACTGGAACTACATGTAGTGAAGCGAGGAAAAAACCTGAGTGAGGGTAAGGTTTGGAAT
AAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References