Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4149472..4150013 Replicon chromosome
Accession NZ_CP049185
Organism Shigella sonnei strain 19.0821.3486

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag G6O60_RS21075 Protein ID WP_000615976.1
Coordinates 4149472..4149750 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag G6O60_RS21080 Protein ID WP_000729704.1
Coordinates 4149753..4150013 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O60_RS21060 (4147054) 4147054..4147632 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
G6O60_RS21065 (4147838) 4147838..4148605 + 768 WP_000333380.1 class II glutamine amidotransferase -
G6O60_RS21070 (4148576) 4148576..4149316 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
G6O60_RS21075 (4149472) 4149472..4149750 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
G6O60_RS21080 (4149753) 4149753..4150013 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
G6O60_RS21085 (4150199) 4150199..4150972 + 774 WP_127148796.1 C40 family peptidase -
G6O60_RS21095 (4152013) 4152013..4152141 + 129 Protein_4107 ISAs1 family transposase -
G6O60_RS21100 (4152212) 4152212..4152709 + 498 WP_000006258.1 REP-associated tyrosine transposase RayT -
G6O60_RS21105 (4152832) 4152832..4154544 - 1713 Protein_4109 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T150850 WP_000615976.1 NZ_CP049185:c4149750-4149472 [Shigella sonnei]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T150850 NZ_CP065047:c4719009-4718554 [Mycobacterium kubicae]
ATGGCGAAACTTTCTGGATCCATCGACGTCCCGCTGCCTCCTGAGGAGGCGTGGAATCATGCCTCCGACCTGTCGCGGTA
CAAGGAGTGGCTGACCATCCACAAGGTCTGGCGCAGCCCGCTGCCCGATGTCATCGAGAAGGGCACGGTCGTCGAGTCCT
ATGTCGAGGTCAAGGGCATGCCCAACCGCATCAAGTGGACGGTGGTGCGGTACAAGCCGCCGGAAGGCATGACGCTCAAC
GGTGACGGTGTCGGCGGGGTGAAGGTGAAGCTGATGGCCAAGGTCGCCCCCAAGGGCGACGGCTCGGTGGTCAGCTTCGA
CGTGCACCTCGGCGGGCCGGCGCTGTTCGGGCCCATCGGCATGGTGGTCGCGGCGGCGCTGAAGACCGACATTCGGGAGT
CGTTGCAGAACTTCCTCGCGGTGTTCGCCGGTTCGGAGCGCAAGCCGTCCGGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT150850 WP_000729704.1 NZ_CP049185:c4150013-4149753 [Shigella sonnei]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT150850 NZ_CP065047:c4719193-4719014 [Mycobacterium kubicae]
ATGGGATTCGTGGACAAAGCCAAGGACCTGCTGTCGCAGAACGCCGACAAGGTCGAAACCGCAATCACCAAGGCCGGCGA
GTTCGTCGACGAGAAGACGCAAGGCAAGTACACCGACACCATTCACAAGGTGCAGGAACAGGCCAGGAAAGTCGTCGACA
CCGGCGAACAACAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References