150807

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3772646..3773373 Replicon chromosome
Accession NZ_CP049177
Organism Shigella sonnei strain 1205.3131

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag G6O63_RS19175 Protein ID WP_000550189.1
Coordinates 3772646..3772960 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G6O63_RS19180 Protein ID WP_000560263.1
Coordinates 3772957..3773373 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O63_RS19155 (3768812) 3768812..3769798 - 987 WP_001446103.1 Gfo/Idh/MocA family oxidoreductase -
G6O63_RS19160 (3769877) 3769877..3770560 - 684 WP_001183060.1 vancomycin high temperature exclusion protein -
G6O63_RS19165 (3770637) 3770637..3771140 - 504 WP_001305117.1 M48 family metallopeptidase -
G6O63_RS19170 (3771225) 3771225..3772361 + 1137 WP_000018685.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
G6O63_RS19175 (3772646) 3772646..3772960 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
G6O63_RS19180 (3772957) 3772957..3773373 + 417 WP_000560263.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
G6O63_RS19185 (3773418) 3773418..3775436 - 2019 WP_000121451.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
G6O63_RS19190 (3775662) 3775662..3778013 - 2352 WP_000695471.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T150807 WP_000550189.1 NZ_CP049177:3772646-3772960 [Shigella sonnei]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T150807 NZ_CP065036:443724-444137 [Pectobacterium parmentieri]
GTGGCCCAGTGGCAATGTGACCTTCGCGTTTCCTGGCGCATGCAACTGCTGTCATTGGTTGTGCATGGTCTATTAGTGTT
GCTCATTCTGCTGGCACCGTGGCCGGACGGCTATGCGTGGCTGTGGCTGTGTTTGGTCACAATGGTGATGTTTGGTTTCA
TCCGTAGCCAAAGGAATATCAAATCGCGGCAAGGGTGCATCACGCTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAGTGGCGGATTGTCAAACGACCGTGGTTGCTGAAAAATGGTGTGTTATTGGCATTGCAATCGGCTAATGGGAAAGACAA
GCAACAACTGTGGCTGGCATCGGACAGCATGGGCGATGACGAATGGCGTCATCTGCGCCAGCTTCTTTTGCAGCAAAAAC
ACTGGGCGAGATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14979.42 Da        Isoelectric Point: 4.4547

>AT150807 WP_000560263.1 NZ_CP049177:3772957-3773373 [Shigella sonnei]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLADLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT150807 NZ_CP065036:443477-443743 [Pectobacterium parmentieri]
ATGGAAATCGATAACAAATCACGTATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTGGATATCGCCATCATGCCGTT
TTTTGAGCATGACTATGACACATTAAACGATATAGATAAGCGCACGTTTGTACGCCTGCTACAAAGCGACGATCCCGATT
TATTCAACTGGCTAATGAACCACGGTGAGCCAGAAGACGGAGAGCTAAAACGCATGATTTCCCTTATCCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References