Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 2671713..2672215 | Replicon | chromosome |
| Accession | NZ_CP049177 | ||
| Organism | Shigella sonnei strain 1205.3131 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | G6O63_RS13700 | Protein ID | WP_000767829.1 |
| Coordinates | 2671713..2671967 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | G6O63_RS13705 | Protein ID | WP_001259255.1 |
| Coordinates | 2671964..2672215 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6O63_RS13670 (2666728) | 2666728..2666955 | - | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| G6O63_RS13675 (2666969) | 2666969..2668027 | - | 1059 | WP_000492295.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| G6O63_RS13680 (2668206) | 2668206..2669564 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| G6O63_RS13685 (2669554) | 2669554..2669616 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| G6O63_RS13690 (2669831) | 2669831..2670760 | - | 930 | WP_000811606.1 | LysR substrate-binding domain-containing protein | - |
| G6O63_RS13695 (2670806) | 2670806..2671630 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| G6O63_RS13700 (2671713) | 2671713..2671967 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| G6O63_RS13705 (2671964) | 2671964..2672215 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| G6O63_RS13710 (2672498) | 2672498..2672548 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| G6O63_RS13715 (2672694) | 2672694..2673593 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| G6O63_RS13720 (2673599) | 2673599..2674903 | + | 1305 | WP_001462576.1 | histidinol dehydrogenase | - |
| G6O63_RS13725 (2674900) | 2674900..2675970 | + | 1071 | WP_000108977.1 | histidinol-phosphate transaminase | - |
| G6O63_RS13730 (2675970) | 2675970..2677037 | + | 1068 | WP_000080086.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T150803 WP_000767829.1 NZ_CP049177:c2671967-2671713 [Shigella sonnei]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T150803 NZ_CP065036:127811-128131 [Pectobacterium parmentieri]
ATGCAAACATCACCTGCAATCCCGCCACGGGAGGATAACCCCTGTCCGTCACCCATAGCCGCCTGGCAGCAACTGCTGAC
CTACCTGCTGGAAAAGCACTACGGCCTGACGCTGAACGACACGCCGTTCTGTGAGGAAAACGTGATTCAGGAACATATCG
ATGCTGGCATCACATTGGTCAATGCCGTGAATTTTCTGGTGGAGAAATACGAACTGGTGCGTATCGACCGCGACGGTTTT
AACTGGCAGGAGCAATCACCGTTTCTTACTGCCGTTGATGTTCTCCGTGCCAGACGTGCTAACGGCTTGCTCAAAGCATA
A
ATGCAAACATCACCTGCAATCCCGCCACGGGAGGATAACCCCTGTCCGTCACCCATAGCCGCCTGGCAGCAACTGCTGAC
CTACCTGCTGGAAAAGCACTACGGCCTGACGCTGAACGACACGCCGTTCTGTGAGGAAAACGTGATTCAGGAACATATCG
ATGCTGGCATCACATTGGTCAATGCCGTGAATTTTCTGGTGGAGAAATACGAACTGGTGCGTATCGACCGCGACGGTTTT
AACTGGCAGGAGCAATCACCGTTTCTTACTGCCGTTGATGTTCTCCGTGCCAGACGTGCTAACGGCTTGCTCAAAGCATA
A
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT150803 WP_001259255.1 NZ_CP049177:c2672215-2671964 [Shigella sonnei]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT150803 NZ_CP065036:127417-127752 [Pectobacterium parmentieri]
ATGTCATTATCGGATACCCCGGAATGGGGACTAAAAAGTGCCATCACTCCGCGATTCGGAGCCAGACTGGTGCAGGAGGG
TAACCGTCTGCATTATCTGGCAGACCGGGTCAGCTTTATCGGTACGTTTAGCAAAACAGAAGCCCAAAGTCTGGAACGTT
GCTTCCCTGAGCTAATTAAGCTGTTGGAACAGAAGCTACGCATGGGGGAACTGAATCCCCGGCAGCAGGGTTGCATCACG
TTGTATTGCAACGAATGGACCTGTGAAGCCGATACGCTGGGCAGTTTTGGCTACGTGTATATTGCTATTTATCCCTCTTC
AGCGGCAACACAATAA
ATGTCATTATCGGATACCCCGGAATGGGGACTAAAAAGTGCCATCACTCCGCGATTCGGAGCCAGACTGGTGCAGGAGGG
TAACCGTCTGCATTATCTGGCAGACCGGGTCAGCTTTATCGGTACGTTTAGCAAAACAGAAGCCCAAAGTCTGGAACGTT
GCTTCCCTGAGCTAATTAAGCTGTTGGAACAGAAGCTACGCATGGGGGAACTGAATCCCCGGCAGCAGGGTTGCATCACG
TTGTATTGCAACGAATGGACCTGTGAAGCCGATACGCTGGGCAGTTTTGGCTACGTGTATATTGCTATTTATCCCTCTTC
AGCGGCAACACAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|