Detailed information of TA system TA150765

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2755..3181
• Replicon: plasmid p19-0820-1561
• Accession: NZ_CP049174
• Organism: Shigella sonnei strain 19.0820.1561

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: G6O61_RS24180
• Protein ID: WP_001372321.1
• Coordinates: 2755..2880 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	2957..3181 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6O61_RS24165 (615)	615..1433	-	819	WP_254000587.1	DUF932 domain-containing protein	-
G6O61_RS24170 (1544)	1544..1840	-	297	WP_001272251.1	hypothetical protein	-
G6O61_RS24175 (2140)	2140..2436	+	297	Protein_3	hypothetical protein	-
G6O61_RS24180 (2755)	2755..2880	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
G6O61_RS24185 (2822)	2822..2971	-	150	Protein_5	plasmid maintenance protein Mok	-
G6O61_RS24190 (2993)	2993..3172	+	180	WP_001309233.1	hypothetical protein	-
- (2957)	2957..3181	-	225	NuclAT_0	-	Antitoxin
- (2957)	2957..3181	-	225	NuclAT_0	-	Antitoxin
- (2957)	2957..3181	-	225	NuclAT_0	-	Antitoxin
- (2957)	2957..3181	-	225	NuclAT_0	-	Antitoxin
G6O61_RS24195 (3193)	3193..3912	-	720	WP_001276217.1	plasmid SOS inhibition protein A	-
G6O61_RS24200 (3909)	3909..4343	-	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
G6O61_RS24205 (4412)	4412..6435	-	2024	Protein_9	ParB/RepB/Spo0J family partition protein	-
G6O61_RS24210 (6496)	6496..6729	-	234	WP_000006003.1	DUF905 family protein	-
G6O61_RS24215 (6787)	6787..7314	-	528	WP_000290834.1	single-stranded DNA-binding protein	-
G6O61_RS24220 (7616)	7616..8065	+	450	Protein_12	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T150765 WP_001372321.1 NZ_CP049174:c2880-2755 [Shigella sonnei]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T150765 NZ_CP065031:146023-146505 [Pectobacterium brasiliense]
ATGGGAATAACTGCGCCAGAGCCATTATCTTCCAGCCATAATCTTGCTGAATTTTGCAGCCAAGAACCGAGCTTGAATGA
ATGGCTAAAAAAGAAAGCGCTAAAAAATCATAGTGCAGGGATTTCTCGTGTATATGTGATTTGCGCTGAAGGCACACATC
AGGTGATTGGATATTATTGTTTATCAACAGGTAGCGTTCAGAGAAATACAGCGCCTGGTGCATATAGACGTAATGCCCCC
GAATCACTACCAGTCATTGTCCTTGGGCGGCTTGCCATTGATCAGGCGTATTCTGGTAAAGGTTTAGGTGTGGCTTTATT
AAAAGACGCGATATTTCGGACTGAGAATATTGCTTTGCAAGTGGGTGTGAGGGCATTAGTCGTTCACGCGCTGGATGAGA
ACGTGCGCAATTTCTACCTTAAATTCGCTTTTGATCCCTCGCCAGTGCAGCCCCTGATGCTACTCTATCCAATTAAAATT
TAG

Antitoxin

Nucleotide

• Length: 225 bp

>AT150765 NZ_CP049174:c3181-2957 [Shigella sonnei]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin