Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4457582..4458309 Replicon chromosome
Accession NZ_CP049173
Organism Shigella sonnei strain 19.0820.1561

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag G6O61_RS22505 Protein ID WP_000550189.1
Coordinates 4457995..4458309 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G6O61_RS22500 Protein ID WP_000560263.1
Coordinates 4457582..4457998 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O61_RS22490 (4452942) 4452942..4455293 + 2352 WP_000695471.1 alpha-glucosidase -
G6O61_RS22495 (4455519) 4455519..4457537 + 2019 WP_000121451.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
G6O61_RS22500 (4457582) 4457582..4457998 - 417 WP_000560263.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
G6O61_RS22505 (4457995) 4457995..4458309 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
G6O61_RS22510 (4458594) 4458594..4459730 - 1137 WP_000018685.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
G6O61_RS22515 (4459815) 4459815..4460318 + 504 WP_001305117.1 M48 family metallopeptidase -
G6O61_RS22520 (4460395) 4460395..4461078 + 684 WP_001183060.1 vancomycin high temperature exclusion protein -
G6O61_RS22525 (4461157) 4461157..4462143 + 987 WP_001446103.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T150761 WP_000550189.1 NZ_CP049173:c4458309-4457995 [Shigella sonnei]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T150761 NZ_CP065030:3378115-3378459 [Pectobacterium versatile]
ATGAAATCACTCTACTGGGTTGGCAGTAGCAAAAAGGATCTCCAGTCGCTACCTGCAGATGTGCAGGATGTGTTCGGTTA
TGCACTTCATCTGGCTCAAACTGGTGGTAAACACACTCAAGCTAAGCCGCTGAAAGGTTTTGGTGGTGCGGGCGTATTAG
AAGTCGTTGAGGATTATATCGGCGATACTTATCGCGCAGTCTACACCGTCAGATTTGGAGAAGCAGTATACGTTCTACAT
GCTTTTCAGAAAAAATCGTCATCTGGAATTGCAACACAGAAACCCGATATGAACACCATTCGTGAACGCCTTAAAACCGC
AGAGAATCATGCAAAAGGAGCATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14979.42 Da        Isoelectric Point: 4.4547

>AT150761 WP_000560263.1 NZ_CP049173:c4457998-4457582 [Shigella sonnei]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLADLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT150761 NZ_CP065030:3378461-3378778 [Pectobacterium versatile]
ATGAGCCAGGATATTGAAGTCAGCAGCGGTAATGTATACGCCGACCTTGGTAACTTGCATGCTGAAGATATGTTGGTCAA
AGCGCAGCTTGCTACCCTGATTAGCTCAATCATCAAAAGCCGCCGTCTCACACAGGCAGAAGCAGCGAAGCTATTGGGCA
TGCCCCAACCAAAGCTATCCAACCTATTGCGTGGCCAATTCAGGGGAATCAGCGAAACCAAAATGTTGGAATGCCTTACG
AAGCTGGGACGCGATATACAGATCGTTGTAGGGAAGCCACGCCGCACACCGGGTAGCGTTAAAGTCGTGTTTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References