Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 763845..764347 | Replicon | chromosome |
| Accession | NZ_CP049173 | ||
| Organism | Shigella sonnei strain 19.0820.1561 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | G6O61_RS03805 | Protein ID | WP_000767829.1 |
| Coordinates | 764093..764347 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | G6O61_RS03800 | Protein ID | WP_001259255.1 |
| Coordinates | 763845..764096 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6O61_RS03775 (759023) | 759023..760090 | - | 1068 | WP_000080086.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| G6O61_RS03780 (760090) | 760090..761160 | - | 1071 | WP_039063509.1 | histidinol-phosphate transaminase | - |
| G6O61_RS03785 (761157) | 761157..762461 | - | 1305 | WP_001462576.1 | histidinol dehydrogenase | - |
| G6O61_RS03790 (762467) | 762467..763366 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| G6O61_RS03795 (763512) | 763512..763562 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| G6O61_RS03800 (763845) | 763845..764096 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| G6O61_RS03805 (764093) | 764093..764347 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| G6O61_RS03810 (764430) | 764430..765254 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| G6O61_RS03815 (765300) | 765300..766229 | + | 930 | WP_000811606.1 | LysR substrate-binding domain-containing protein | - |
| G6O61_RS03820 (766444) | 766444..766506 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| G6O61_RS03825 (766496) | 766496..767854 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| G6O61_RS03830 (768033) | 768033..769091 | + | 1059 | WP_000492295.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| G6O61_RS03835 (769105) | 769105..769332 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T150747 WP_000767829.1 NZ_CP049173:764093-764347 [Shigella sonnei]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T150747 NZ_CP065030:126978-127253 [Pectobacterium versatile]
ATGCAGGGAAAAATAGCCAGCCTACGAAAGAAGCAGCGGGAAACGCTGAGCCACATTTTCAAAACACCAATACTTTCAGG
TGTTAAATGGTCGAGTATTGAGTCACTCGTTACTGCGTTAGGCGGTGAAATTAAGGAAGGTAGCGGGTCACGAGTGCGAT
TTTTATTGAACGGGAGTATCGCCCGATTCCATCGTCCTCATCCGTCACCGGATACTGATAAAGGTGCCCTGGTTAGCCTG
CGTGAATGGCTGGAAAGTATAGGAGTAAAACCATGA
ATGCAGGGAAAAATAGCCAGCCTACGAAAGAAGCAGCGGGAAACGCTGAGCCACATTTTCAAAACACCAATACTTTCAGG
TGTTAAATGGTCGAGTATTGAGTCACTCGTTACTGCGTTAGGCGGTGAAATTAAGGAAGGTAGCGGGTCACGAGTGCGAT
TTTTATTGAACGGGAGTATCGCCCGATTCCATCGTCCTCATCCGTCACCGGATACTGATAAAGGTGCCCTGGTTAGCCTG
CGTGAATGGCTGGAAAGTATAGGAGTAAAACCATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT150747 WP_001259255.1 NZ_CP049173:763845-764096 [Shigella sonnei]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT150747 NZ_CP065030:127250-127612 [Pectobacterium versatile]
ATGACGAAAGCACTCAACACACCAAATACGATGGTTGTTTCTGGACAACCTGCCATTATCAGTTACGTACCGGAAATTGG
TATGTTTCGTGGTAAGTTTATTGGCTTATCTGGCTACTGTGATTTTGTCGCCGACAGTATTAATGGCTTGAGAAGCGAGG
GTGAAATTTCGCTACGCGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAGCGTGAAGAGAAGGTGAAA
ACATTCACCCTCCGTTACCCTGAATCATTCGGGGAACGACTGACCATTGCGGCCGCTGAACGTCACATTTCAGTGAATAC
GTTTATTGTTGAAACGCTTAGCGAACACCTGAAACAGGCTTGA
ATGACGAAAGCACTCAACACACCAAATACGATGGTTGTTTCTGGACAACCTGCCATTATCAGTTACGTACCGGAAATTGG
TATGTTTCGTGGTAAGTTTATTGGCTTATCTGGCTACTGTGATTTTGTCGCCGACAGTATTAATGGCTTGAGAAGCGAGG
GTGAAATTTCGCTACGCGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAGCGTGAAGAGAAGGTGAAA
ACATTCACCCTCCGTTACCCTGAATCATTCGGGGAACGACTGACCATTGCGGCCGCTGAACGTCACATTTCAGTGAATAC
GTTTATTGTTGAAACGCTTAGCGAACACCTGAAACAGGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|