Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 4575226..4575728 | Replicon | chromosome |
| Accession | NZ_CP049171 | ||
| Organism | Shigella sonnei strain 0401930105 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | G6O59_RS23095 | Protein ID | WP_000767829.1 |
| Coordinates | 4575226..4575480 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | G6O59_RS23100 | Protein ID | WP_001259255.1 |
| Coordinates | 4575477..4575728 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6O59_RS23065 (4570241) | 4570241..4570468 | - | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| G6O59_RS23070 (4570482) | 4570482..4571540 | - | 1059 | WP_000492295.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| G6O59_RS23075 (4571719) | 4571719..4573077 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| G6O59_RS23080 (4573067) | 4573067..4573129 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| G6O59_RS23085 (4573344) | 4573344..4574273 | - | 930 | WP_000811606.1 | LysR substrate-binding domain-containing protein | - |
| G6O59_RS23090 (4574319) | 4574319..4575143 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| G6O59_RS23095 (4575226) | 4575226..4575480 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| G6O59_RS23100 (4575477) | 4575477..4575728 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| G6O59_RS23105 (4576011) | 4576011..4576061 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| G6O59_RS23110 (4576207) | 4576207..4577106 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| G6O59_RS23115 (4577112) | 4577112..4578416 | + | 1305 | WP_001462576.1 | histidinol dehydrogenase | - |
| G6O59_RS23120 (4578413) | 4578413..4579483 | + | 1071 | WP_000108977.1 | histidinol-phosphate transaminase | - |
| G6O59_RS23125 (4579483) | 4579483..4580550 | + | 1068 | WP_000080086.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T150743 WP_000767829.1 NZ_CP049171:c4575480-4575226 [Shigella sonnei]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T150743 NZ_CP065027:c1740698-1740279 [Actinomyces sp. zg-993]
GTGATAATCCTGGACACCAATGTCATTTCGGAGCCGCTGCGACGATCCCCAGATCCCGCCGTGGCACGGTGGCTCGATGA
TCAGGCACAGTCCAGCCTCTACCTGACTGCTCTTACCGTTGCCGAGTTGTGCACCGGGGTCGAGATGCTTCCTGGAGGGA
GACGCCGGGATAACCTCAGGCAGCGGTTGGAGAGCGACGTCTTTCCGTTCTTCGCGGACCGCGTGCTGCCTTTCGACCTG
GCGGCTGCACAGGCATGGGCTGAGATTCAGACAGAAGCCCGGCGGCGCGGGCGCCCTCTGCCTGTGATGGACTCACTAAT
CGCCTCCATCGCCCGTGTCCACGGCTTCGCCCTGGCCACCCGCAACATCAAGGACCTTGAATCCACGGGCGTTACTCTGA
TCAATCCCTGGACCGACTGA
GTGATAATCCTGGACACCAATGTCATTTCGGAGCCGCTGCGACGATCCCCAGATCCCGCCGTGGCACGGTGGCTCGATGA
TCAGGCACAGTCCAGCCTCTACCTGACTGCTCTTACCGTTGCCGAGTTGTGCACCGGGGTCGAGATGCTTCCTGGAGGGA
GACGCCGGGATAACCTCAGGCAGCGGTTGGAGAGCGACGTCTTTCCGTTCTTCGCGGACCGCGTGCTGCCTTTCGACCTG
GCGGCTGCACAGGCATGGGCTGAGATTCAGACAGAAGCCCGGCGGCGCGGGCGCCCTCTGCCTGTGATGGACTCACTAAT
CGCCTCCATCGCCCGTGTCCACGGCTTCGCCCTGGCCACCCGCAACATCAAGGACCTTGAATCCACGGGCGTTACTCTGA
TCAATCCCTGGACCGACTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT150743 WP_001259255.1 NZ_CP049171:c4575728-4575477 [Shigella sonnei]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT150743 NZ_CP065027:c1740934-1740695 [Actinomyces sp. zg-993]
ATGCCTTCGATGGTCATTAGGAACCTGCCAGAGCGGACACATCAGGCACTCAAGGCTAGAGCTCGGCGCCACGGCCGCAG
CACAGAGGCTGAGGCCCGCGCGGTGCTAGGTGAGGCGGTCGCCGAGGAAGCTGGTCAGCGCCTGGGGAGCATCCTGACCT
CTATACGGCAAGAAGTCGGCGAACTAGACCTGGACGGTATCCGCGATGCTGCGCCATACGAGCCTATGGACCTGTCGTGA
ATGCCTTCGATGGTCATTAGGAACCTGCCAGAGCGGACACATCAGGCACTCAAGGCTAGAGCTCGGCGCCACGGCCGCAG
CACAGAGGCTGAGGCCCGCGCGGTGCTAGGTGAGGCGGTCGCCGAGGAAGCTGGTCAGCGCCTGGGGAGCATCCTGACCT
CTATACGGCAAGAAGTCGGCGAACTAGACCTGGACGGTATCCGCGATGCTGCGCCATACGAGCCTATGGACCTGTCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|