Detailed information of TA system TA150725

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 82157..82426
• Replicon: plasmid p19-1125-3493
• Accession: NZ_CP049170
• Organism: Shigella sonnei strain 19.1125.3493

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: G6O58_RS24620
• Protein ID: WP_001372321.1
• Coordinates: 82301..82426 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	82157..82222 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6O58_RS24585	77867..78394	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
G6O58_RS24590	78452..78685	+	234	WP_000006003.1	DUF905 family protein	-
G6O58_RS24595	78746..80769	+	2024	Protein_94	ParB/RepB/Spo0J family partition protein	-
G6O58_RS24600	80838..81272	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
G6O58_RS24605	81269..81988	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	82000..82224	+	225	NuclAT_0	-	-
-	82000..82224	+	225	NuclAT_0	-	-
-	82000..82224	+	225	NuclAT_0	-	-
-	82000..82224	+	225	NuclAT_0	-	-
G6O58_RS24610	82009..82188	-	180	WP_001309233.1	hypothetical protein	-
-	82157..82222	+	66	-	-	Antitoxin
G6O58_RS24615	82210..82359	+	150	Protein_98	plasmid maintenance protein Mok	-
G6O58_RS24620	82301..82426	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
G6O58_RS24625	82745..83041	-	297	Protein_100	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T150725 WP_001372321.1 NZ_CP049170:82301-82426 [Shigella sonnei]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T150725 NZ_CP065020:658463-658726 [Sinorhizobium meliloti]
ATGCGAATTGTGTGGGGCGAACCCAAACGGCGAGCCAACCTTGAGAAGCATGGTTTCGATTTTGCCGATGTAAGCGACCT
CGATTGGGCGAGTGCCCTCATAGAGGACAGCAAGCCAGATACTTCTGGCAGAAAGCGCCTGAAGGCTATCGGTTATTTTC
GTGACGGGACGGCAGCGGTCATTTTCGCGACACTCGGAACGGAAGCTATATCGATCATCAGCTTTCGTCCTGCAAGCGAC
AGAGAAAGAAGGAGGCTTCCATGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT150725 NZ_CP049170:82157-82222 [Shigella sonnei]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Structures

Antitoxin