Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 3256363..3256865 | Replicon | chromosome |
Accession | NZ_CP049169 | ||
Organism | Shigella sonnei strain 19.1125.3493 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | U9YDH0 |
Locus tag | G6O58_RS16070 | Protein ID | WP_000767829.1 |
Coordinates | 3256611..3256865 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | S1Q063 |
Locus tag | G6O58_RS16065 | Protein ID | WP_001259255.1 |
Coordinates | 3256363..3256614 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
G6O58_RS16040 (3251541) | 3251541..3252608 | - | 1068 | WP_000080086.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
G6O58_RS16045 (3252608) | 3252608..3253678 | - | 1071 | WP_000108977.1 | histidinol-phosphate transaminase | - |
G6O58_RS16050 (3253675) | 3253675..3254979 | - | 1305 | WP_001462576.1 | histidinol dehydrogenase | - |
G6O58_RS16055 (3254985) | 3254985..3255884 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
G6O58_RS16060 (3256030) | 3256030..3256080 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
G6O58_RS16065 (3256363) | 3256363..3256614 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
G6O58_RS16070 (3256611) | 3256611..3256865 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
G6O58_RS16075 (3256948) | 3256948..3257772 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
G6O58_RS16080 (3257818) | 3257818..3258747 | + | 930 | WP_000811606.1 | LysR substrate-binding domain-containing protein | - |
G6O58_RS16085 (3258962) | 3258962..3259024 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
G6O58_RS16090 (3259014) | 3259014..3260372 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
G6O58_RS16095 (3260551) | 3260551..3261609 | + | 1059 | WP_000492295.1 | thiosulfate utilization transporter TsuA/YeeE | - |
G6O58_RS16100 (3261623) | 3261623..3261850 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T150715 WP_000767829.1 NZ_CP049169:3256611-3256865 [Shigella sonnei]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T150715 NZ_CP064939:5354759-5355058 [Pedobacter sp. JBR3-12]
ATGAGGTATAAAATTAGTGACGAGGCTCAAAACGACATAGAAAATATTTGGCTTTATACTTTCGAAACCTGGTCCGCAGG
TCAAGCCGACAAATATTATAATTTATTACTTGATGAAATTGAATATTTAGCCGAAAACCCGGAGGCTGGAAAAAAATATG
ACCACGTAAGAAAAGGATATTTACGTTCGAACATACAATCTCACATTATTTTCTATAAAATCAATCAGGAAGAAAACGCG
ATAGAGATTATTAGAATATTACATCAGCGAATGGATATTGATGCTGGTTTAAATGAATAA
ATGAGGTATAAAATTAGTGACGAGGCTCAAAACGACATAGAAAATATTTGGCTTTATACTTTCGAAACCTGGTCCGCAGG
TCAAGCCGACAAATATTATAATTTATTACTTGATGAAATTGAATATTTAGCCGAAAACCCGGAGGCTGGAAAAAAATATG
ACCACGTAAGAAAAGGATATTTACGTTCGAACATACAATCTCACATTATTTTCTATAAAATCAATCAGGAAGAAAACGCG
ATAGAGATTATTAGAATATTACATCAGCGAATGGATATTGATGCTGGTTTAAATGAATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT150715 WP_001259255.1 NZ_CP049169:3256363-3256614 [Shigella sonnei]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT150715 NZ_CP064939:5354511-5354762 [Pedobacter sp. JBR3-12]
ATGGCAAAAAACACATCTATACTGTTAGGCGATTATTTTGAGGATTTTATCAGTCAGCAAGTTAAATCCGGAAAGTTTTC
ATCGGCAAGCGAAGTTATAAGAGCAGCATTGAGAATGTTTGAGTATGAAGAAACTAGAAAAGCCGAACTCATTAATGAGC
TGAAAAAGGGAGAAAAATCTGGCTTTGCAAATGAGTTTAATCGAGACGTTGTTTTAAAGACGCTTCATGAAAAACATCTT
GCAAAAGAATGA
ATGGCAAAAAACACATCTATACTGTTAGGCGATTATTTTGAGGATTTTATCAGTCAGCAAGTTAAATCCGGAAAGTTTTC
ATCGGCAAGCGAAGTTATAAGAGCAGCATTGAGAATGTTTGAGTATGAAGAAACTAGAAAAGCCGAACTCATTAATGAGC
TGAAAAAGGGAGAAAAATCTGGCTTTGCAAATGAGTTTAATCGAGACGTTGTTTTAAAGACGCTTCATGAAAAACATCTT
GCAAAAGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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