Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1392706..1393433 Replicon chromosome
Accession NZ_CP049167
Organism Shigella sonnei strain 09163633

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag G6O57_RS06895 Protein ID WP_000550189.1
Coordinates 1393119..1393433 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G6O57_RS06890 Protein ID WP_000560263.1
Coordinates 1392706..1393122 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O57_RS06880 (1388066) 1388066..1390417 + 2352 WP_171796990.1 alpha-glucosidase -
G6O57_RS06885 (1390643) 1390643..1392661 + 2019 WP_000121451.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
G6O57_RS06890 (1392706) 1392706..1393122 - 417 WP_000560263.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
G6O57_RS06895 (1393119) 1393119..1393433 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
G6O57_RS06900 (1393718) 1393718..1394854 - 1137 WP_000018685.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
G6O57_RS06905 (1394939) 1394939..1395442 + 504 WP_001305117.1 M48 family metallopeptidase -
G6O57_RS06910 (1395519) 1395519..1396202 + 684 WP_001183060.1 vancomycin high temperature exclusion protein -
G6O57_RS06915 (1396281) 1396281..1397267 + 987 WP_001446103.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T150686 WP_000550189.1 NZ_CP049167:c1393433-1393119 [Shigella sonnei]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T150686 NZ_CP064908:c2864663-2864244 [Synechococcus sp. CBW1107]
GTGTTCCTGATTGACACCGTGGTGCTCTCCGAGCTGCGAAGGCGCCAAAGAGACCCAGGCGTGGTGGCCTGGATCGGCAG
CCAGCGGCAGGAGGATTGTTTTCTGAGTGTGGTGAGCATCGGCGAAATCGAACGCGGCATTGCCCGCAAGCGCACGACCG
ATTCCAGATTTGCGCAGCAGTTGGCCGGATGGCTGGATCAGCTGCTGCGGCTCTATGGCGATCGGCTGCTGCCGGTGGAT
GTGGGGGTGGCGCGTCGCTGGGGACAACTCTCGGCCGAGCTCGGCCATGACGGAGCCGATCTGCTGATTGCTGCCACGGC
GCTGGAGCGCGGCCTCACGGTCGTGACGCGCAACCTGCGCCACTTCACGCCCACTGGGGTTCAGACCCTGGACCCATGGA
GCCCGGAGGCTGGCATCTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14979.42 Da        Isoelectric Point: 4.4547

>AT150686 WP_000560263.1 NZ_CP049167:c1393122-1392706 [Shigella sonnei]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLADLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT150686 NZ_CP064908:c2864914-2864654 [Synechococcus sp. CBW1107]
ATGGACGCGGTGTGGACGCTGCAGGACGCCAAGAATCGCTTCAGTGCAGTGGTGGATGCGGCCGCCCGGGGGGAACCGCA
GAAGGTGACGCGGCGCGGCACGTGGGTGAGTGTGGTGCTCTCGGCCGAGGAGTACGAGCGGCTGCGGCGCCTCGACCAGG
CCAACGCCCCATCACTGGCGGAGCTGCTCCTGCAGATGCCGCAGGACGACGAGTCCTTTGAGCGTCTGCCCCTGGCGGCG
CGGGATTTCCCGTGTTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References