Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5253055..5253650 Replicon chromosome
Accession NZ_CP049161
Organism Pseudomonas aeruginosa strain MS14403

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag WPAWT_RS24240 Protein ID WP_003113526.1
Coordinates 5253372..5253650 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag WPAWT_RS24235 Protein ID WP_003111575.1
Coordinates 5253055..5253360 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WPAWT_RS24200 5248206..5249054 + 849 WP_171978685.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
WPAWT_RS24210 5249221..5250162 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
WPAWT_RS24215 5250279..5250893 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
WPAWT_RS24220 5250935..5251519 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
WPAWT_RS24225 5251560..5252660 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
WPAWT_RS24235 5253055..5253360 - 306 WP_003111575.1 HigA family addiction module antidote protein Antitoxin
WPAWT_RS24240 5253372..5253650 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WPAWT_RS24245 5253979..5256207 + 2229 WP_171978686.1 TonB-dependent siderophore receptor -
WPAWT_RS24250 5256277..5256924 - 648 WP_003095021.1 carbonate dehydratase -
WPAWT_RS24255 5256986..5258224 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T150662 WP_003113526.1 NZ_CP049161:c5253650-5253372 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T150662 NZ_CP064871:634835-636100 [Xanthomonas oryzae pv. oryzicola]
ATGAAAAACAAGACAGACATTGCTGGCATAGCCGGACTTTCTACGTCTCATGTTTCCTTTGATGACGCAGAATCCAAAAG
CGTCCTAGATGGATCAACACAGTCTACGCCGGAGTACAAATTCCAGACCCCGCTTGATCAGTTGCCGGCTAGGCCCGCTG
GTCCGAAGAGCAGTAACACAACTGATGCTTACATTCATGAATCACTGCCGCATTCGGTTCCAATCGCAGGTGCATCGACC
TCCGCGGCGACACATCAACAGGCTACTCAGCGTAAAGGCACCGATGAGATCTATGGTTTGGGCAGCCTCCCATCTGCTGG
TCCAGAGCGATGGGATTATCTTGCGAATCCGGGGAACTGGCATCCCGAACGCCGTAAGTTACACGAAAAGCTATTAGATC
AAGCGCGATCTTCTGCCTTGACCCTGGCAGAATCCCTTGAGAGTGATGGCTGCCAACCGACATTGTTTGCGCTGCGCGGA
AATACCGCAACGGGTAAAACACGGATTGCGACAAAAAAGATCCCGGTGCTCGCAGCAGCTCTGAAGAAGACAGGTGGGAA
AGGTTGCGTGAATCCAGATGTATTCAAGAGTTCGCTTGCGAAATCCGAGGCAGGCGCCAAGATATTTAGTTCGGCACAAG
TGCATAGCGAGTCATCTTTTCTTGCCGACCGGTTTGAAGGCGGACTTCGCTCTCAAAAGACGGGCAGCGGTGCAATCGCT
AGCATTGTTGTCGACAAGCGCTTGTCAAGAGCGTACGAAATTGATAGCTACATACAACTAGCGAAAGAAACCGGTAGAAA
AGTGGAATTGTGCGATATCGACGCGCCCCTAGAGAATTCTTTGGTGGGAGTTTTGCAGCGAAAACCGGAAGGTGAAGATC
CTAGGCCTCCGTACCCTGTAGTCTCGAGTGGATTTGTAGCCGTACGGAGCAATAGAATGTACGTGATAGACAGGTTCATT
GCCGATCCGAGCCTGGGAAACTACCGACTATTCGGAACAGCTGAAGATGGTGAGAAGGTCATGGTTGCTAGCGTGATTGG
CGGTGAGTTTAGTGTAGAGAATGCTGAGTTGTATGAAAAAATCACGTCCCCACAGCTCTCGGTTACGGGCGATTTGGCTG
ATAAGGTAATCGACAAGGAATTGATTGATCGTCTGAAAAATAATATAGCTGACCCCGAGCGGGCGGCCAAGACGCAAGCC
GCCCTGGAAAAATACAGCGGTAAGTCATGGTCGGCCGCGCTAGCTGCTCACAGCGAGCTAATTTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT150662 WP_003111575.1 NZ_CP049161:c5253360-5253055 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp

>AT150662 NZ_CP064871:636118-636414 [Xanthomonas oryzae pv. oryzicola]
ATGAAAACTTTGACAGGCGCAGACGCACTCGAATTTCATAAGAAGCTTAAGGAACGTAATAAAGCCTTACATGCTTCCGA
CCTCGAGTTAGCACTGGTGCACGCCGATGCTGTCGGCAAAGAACGGTTCGATCTCGAGGAGCTGGAGAAAATTTGCGATA
CCAGCGATGCGGGGCGCCTTACTGATGCGAAAGAGCGACACGACATATATGAAAGGATGTACTACGTTGAGTATCCCAAC
GTTATGACGTTAAAGGAATTCGCTCATATCGTCGAGACACTTTCCTCGTGGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References