Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4631935..4632616 Replicon chromosome
Accession NZ_CP049161
Organism Pseudomonas aeruginosa strain MS14403

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag WPAWT_RS21380 Protein ID WP_015503432.1
Coordinates 4632251..4632616 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag WPAWT_RS21375 Protein ID WP_016561576.1
Coordinates 4631935..4632258 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WPAWT_RS21335 4627827..4628510 - 684 WP_003120766.1 TetR/AcrR family transcriptional regulator -
WPAWT_RS21340 4628598..4629476 + 879 WP_003163191.1 hypothetical protein -
WPAWT_RS21350 4630079..4630306 + 228 WP_014603215.1 hypothetical protein -
WPAWT_RS21355 4630321..4630863 - 543 WP_019396018.1 tyrosine-type recombinase/integrase -
WPAWT_RS21360 4631038..4631313 - 276 WP_004353146.1 hypothetical protein -
WPAWT_RS21365 4631313..4631645 - 333 WP_016561578.1 hypothetical protein -
WPAWT_RS21370 4631700..4631819 + 120 Protein_4226 IS5/IS1182 family transposase -
WPAWT_RS21375 4631935..4632258 - 324 WP_016561576.1 XRE family transcriptional regulator Antitoxin
WPAWT_RS21380 4632251..4632616 - 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WPAWT_RS21385 4632880..4633122 - 243 WP_043884955.1 hypothetical protein -
WPAWT_RS21390 4633329..4633601 + 273 WP_003085667.1 hypothetical protein -
WPAWT_RS21395 4633620..4634045 - 426 WP_003114206.1 ring-cleaving dioxygenase -
WPAWT_RS21400 4634146..4635030 + 885 WP_003454589.1 LysR family transcriptional regulator -
WPAWT_RS21405 4635003..4635956 - 954 WP_003085661.1 LysR family transcriptional regulator -
WPAWT_RS21410 4636177..4636611 + 435 WP_016253806.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T150660 WP_015503432.1 NZ_CP049161:c4632616-4632251 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

>T150660 NZ_CP064871:389911-390063 [Xanthomonas oryzae pv. oryzicola]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11903.72 Da        Isoelectric Point: 5.8900

>AT150660 WP_016561576.1 NZ_CP049161:c4632258-4631935 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQSRGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp

>AT150660 NZ_CP064871:390138-390272 [Xanthomonas oryzae pv. oryzicola]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References