Detailed information of TA system TA150647

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1356799..1357392
• Replicon: chromosome
• Accession: NZ_CP049156
• Organism: Caballeronia sp. SBC1

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: SBC1_RS05880
• Protein ID: WP_206366019.1
• Coordinates: 1357114..1357392 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SBC1_RS05875
• Protein ID: WP_165088512.1
• Coordinates: 1356799..1357101 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBC1_RS05865	1353600..1355306	-	1707	WP_165088506.1	single-stranded-DNA-specific exonuclease RecJ	-
SBC1_RS05870	1355384..1356493	-	1110	WP_165088509.1	regulator	-
SBC1_RS05875	1356799..1357101	-	303	WP_165088512.1	HigA family addiction module antidote protein	Antitoxin
SBC1_RS05880	1357114..1357392	-	279	WP_206366019.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SBC1_RS05885	1357864..1359117	+	1254	WP_165088520.1	lipoprotein-releasing ABC transporter permease subunit	-
SBC1_RS05890	1359110..1359817	+	708	WP_165088523.1	lipoprotein-releasing ABC transporter ATP-binding protein LolD	-
SBC1_RS05895	1359851..1360639	+	789	WP_165088528.1	TatD family hydrolase	-
SBC1_RS39605	1360683..1361402	-	720	WP_206366020.1	hypothetical protein	-
SBC1_RS05905	1361665..1361850	+	186	Protein_1164	TatD family hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-86)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10474.08 Da
• Isoelectric Point: 10.1581

>T150647 WP_206366019.1 NZ_CP049156:c1357392-1357114 [Caballeronia sp. SBC1]
MIQTFRCKDTQALYEGGTPKRFRAIADVAIRRLSALDAAVEIRDLKSPPGNRLESLAGDRRGQLSIRINGQWRVCFKWTT
KGLVDVEIIDYH

Nucleotide

• Length: 279 bp

>T150647 NZ_CP064855:1839941-1840312 [Erwinia amylovora]
ATGATTTATTTTCTATCCAGTCAAGACATCATCGGCATTCATCAGCGTATGATCGTCGCTTACGGCGGTCTTGCCGGTTA
TGCCGATCCTGGTCGGATAGAAAGTATGGCAACACGGATTCTGAACCGCCACATCTACGAAGGTGAGGATGATATCTATA
TTCTGGCAGCTGCATATCTGCTGGCCATTGCGCGCGGGCATTGTTTCAATGATGCAAATAAGAGAACCGCATTTGCTTCA
ACTGCTTTATTCCTGCGCCGTAATGGCATTCTTCTTCGCTTTTCCCCAATCCATGAACAGCTGACTGTCTCAGCAGCACA
GGGGAGCCTGGATGTGTGGCACATTGCTGAAGCACTGAAACAGTCGACATAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11572.37 Da
• Isoelectric Point: 8.4844

>AT150647 WP_165088512.1 NZ_CP049156:c1357101-1356799 [Caballeronia sp. SBC1]
MSKNGMRPVHPGEVLREDYLVPLEMSVNALALALNVPATRMHEIVKERRGITADTAYRLARYFDSTPEFWLNLQAMYDLK
TLPTRTEIDRKVEPRELSRA

Nucleotide

• Length: 303 bp

>AT150647 NZ_CP064855:1839723-1839944 [Erwinia amylovora]
ATGCAAGCTATAAACTTTACTACCGCCCGTAACGAACTGGCATCAGTTCTTGATAGCGTTGCCAGCGGTGAGCCAGTTAT
GATCACCCGCAGATCGGCCAAATCCGTGGTTGTGGTTGATGCCGCGCAGTATGAAAAAATGCAAAAAATTCAGGCAGAAT
CGGACTTTGATTGGTTGTTTACAGAACATGGCCAGACGCTTGAAGCTCTTAAAAACCGATGA