Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4160389..4161034 Replicon chromosome
Accession NZ_CP049144
Organism Cronobacter sakazakii strain C79

Toxin (Protein)


Gene name higB Uniprot ID A0A6L3QTA3
Locus tag G4U62_RS19775 Protein ID WP_004388208.1
Coordinates 4160672..4161034 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6L3TU83
Locus tag G4U62_RS19770 Protein ID WP_004388209.1
Coordinates 4160389..4160685 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4U62_RS19760 (G4U62_19715) 4158043..4158891 - 849 WP_148737054.1 DNA-3-methyladenine glycosylase 2 -
G4U62_RS19765 (G4U62_19720) 4159027..4160379 + 1353 WP_148737052.1 molecular chaperone -
G4U62_RS19770 (G4U62_19725) 4160389..4160685 - 297 WP_004388209.1 XRE family transcriptional regulator Antitoxin
G4U62_RS19775 (G4U62_19730) 4160672..4161034 - 363 WP_004388208.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G4U62_RS19780 (G4U62_19735) 4161265..4162512 + 1248 WP_004388207.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
G4U62_RS19785 (G4U62_19740) 4162512..4165634 + 3123 WP_216310081.1 MdtB/MuxB family multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14197.07 Da        Isoelectric Point: 8.0154

>T150630 WP_004388208.1 NZ_CP049144:c4161034-4160672 [Cronobacter sakazakii]
MAWTVIFTDRFNDWYQQQPEGLQDRIAALLWNLRYSGPLVGRPLVDTVKGSRYPNLKELRVQYGGEPWRVFFAFDAERQA
VVLCAGNKRSQKHFYDALIRQAEEEFFLHVQAMERRNENS

Download         Length: 363 bp

>T150630 NZ_CP064847:2865710-2866204 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10837.75 Da        Isoelectric Point: 5.8787

>AT150630 WP_004388209.1 NZ_CP049144:c4160685-4160389 [Cronobacter sakazakii]
MKTLDDVMAGFSPERQAEILRMADEIALEHGLPRIREARAFSQQQLAEIMGVTQPAIAAIEQRGKEIKLLTLKRYVEALG
GKLSLLIELPEGSKVIPV

Download         Length: 297 bp

>AT150630 NZ_CP064847:2865420-2865713 [Escherichia coli]
ATGGCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L3QTA3

Antitoxin

Source ID Structure
AlphaFold DB A0A6L3TU83

References