Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2726691..2727338 Replicon chromosome
Accession NZ_CP049144
Organism Cronobacter sakazakii strain C79

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G4U62_RS12945 Protein ID WP_148736026.1
Coordinates 2726691..2727038 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G4U62_RS12950 Protein ID WP_007869363.1
Coordinates 2727039..2727338 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4U62_RS12920 (G4U62_12895) 2722271..2723281 + 1011 WP_004387466.1 galactose/methyl galactoside ABC transporter permease MglC -
G4U62_RS12925 (G4U62_12900) 2723493..2724206 - 714 WP_004387784.1 outer membrane permeability protein SanA -
G4U62_RS12930 (G4U62_12905) 2724331..2725215 - 885 WP_148736028.1 cytidine deaminase -
G4U62_RS12935 (G4U62_12910) 2725345..2726040 - 696 WP_085660703.1 CidB/LrgB family autolysis modulator -
G4U62_RS12940 (G4U62_12915) 2726037..2726438 - 402 WP_148736027.1 CidA/LrgA family protein -
G4U62_RS12945 (G4U62_12920) 2726691..2727038 + 348 WP_148736026.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G4U62_RS12950 (G4U62_12925) 2727039..2727338 + 300 WP_007869363.1 XRE family transcriptional regulator Antitoxin
G4U62_RS12955 (G4U62_12930) 2727409..2728341 + 933 WP_216309842.1 tRNA dihydrouridine(16) synthase DusC -
G4U62_RS12960 (G4U62_12935) 2728344..2729267 - 924 WP_148736025.1 LysR family transcriptional regulator -
G4U62_RS12965 (G4U62_12940) 2729340..2730299 + 960 WP_148736024.1 MBL fold metallo-hydrolase -
G4U62_RS12975 (G4U62_12950) 2730592..2731365 + 774 WP_012124284.1 SDR family oxidoreductase -
G4U62_RS12980 (G4U62_12955) 2731362..2731928 - 567 WP_063264316.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13464.67 Da        Isoelectric Point: 10.2639

>T150619 WP_148736026.1 NZ_CP049144:2726691-2727038 [Cronobacter sakazakii]
MWTIYLTHEFEYWLARQPQPLQEDVLAALGLLKIKGPHLGRPYADTLKGSRQAGMKELRVQHAGRPIRAFYAFDAHRYAI
VLCAAQKKGDEKRFYRVILRVADKLFSHYLNHREV

Download         Length: 348 bp

>T150619 NZ_CP064847:702346-702660 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTAG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAATC
CAATCCTTTTACTGATAGATGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11093.70 Da        Isoelectric Point: 4.8840

>AT150619 WP_007869363.1 NZ_CP049144:2727039-2727338 [Cronobacter sakazakii]
MKTFDEVLAAQTPEARERIEEKTAQLLLETHLYALREALSVSQTEMARQMGIAQPSVAAIEQRGNEMKISTLKRYVEALG
GTVRLDVELPDGQRFGFTL

Download         Length: 300 bp

>AT150619 NZ_CP064847:702110-702343 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGAAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References