Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1438740..1439341 Replicon chromosome
Accession NZ_CP049144
Organism Cronobacter sakazakii strain C79

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G4U62_RS06805 Protein ID WP_148737434.1
Coordinates 1438740..1439051 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G4U62_RS06810 Protein ID WP_148737460.1
Coordinates 1439051..1439341 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4U62_RS06780 (G4U62_06775) 1433920..1435887 - 1968 WP_038876500.1 glycoside hydrolase family 127 protein -
G4U62_RS21410 1436087..1436326 - 240 Protein_1326 MFS transporter -
G4U62_RS06790 (G4U62_06785) 1436368..1437480 - 1113 Protein_1327 MFS transporter -
G4U62_RS06795 (G4U62_06790) 1437510..1437704 + 195 WP_174775732.1 hypothetical protein -
G4U62_RS06800 (G4U62_06795) 1437741..1438565 + 825 WP_085045461.1 AraC family transcriptional regulator -
G4U62_RS06805 (G4U62_06800) 1438740..1439051 + 312 WP_148737434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G4U62_RS06810 (G4U62_06805) 1439051..1439341 + 291 WP_148737460.1 NadS family protein Antitoxin
G4U62_RS06815 (G4U62_06810) 1439415..1440344 - 930 WP_007871963.1 formate dehydrogenase accessory protein FdhE -
G4U62_RS06820 (G4U62_06815) 1440341..1440976 - 636 WP_004385165.1 formate dehydrogenase cytochrome b556 subunit -
G4U62_RS06825 (G4U62_06820) 1440973..1441875 - 903 WP_004385164.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12111.06 Da        Isoelectric Point: 9.7588

>T150616 WP_148737434.1 NZ_CP049144:1438740-1439051 [Cronobacter sakazakii]
MLFIETEIFTRAVTALLSDDDYQRLQWFLALRPDYGDVIPDTGGLRKARWLAGGRGKRGGVRIIYFYRPVDDEIRLLLIY
RKGIKDDLSPHEKAVLRMLNERW

Download         Length: 312 bp

>T150616 NZ_CP064847:480848-481198 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10645.16 Da        Isoelectric Point: 10.4419

>AT150616 WP_148737460.1 NZ_CP049144:1439051-1439341 [Cronobacter sakazakii]
MDNALFEQLTESLRQMNDISEGRREPSRVFVIDALKIKAIREASGLSQTKFASLISVSVDTLRNWEQGRRSPTGPARALL
RAIANDPQHVLSALAL

Download         Length: 291 bp

>AT150616 NZ_CP064847:480603-480854 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References