Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4769247..4769941 Replicon chromosome
Accession NZ_CP049139
Organism Herbaspirillum frisingense strain IAC152

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G5S34_RS21645 Protein ID WP_182993024.1
Coordinates 4769247..4769528 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G5S34_RS21650 Protein ID WP_182993025.1
Coordinates 4769516..4769941 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S34_RS21615 4764404..4765027 + 624 WP_182993022.1 lipopolysaccharide transport periplasmic protein LptA -
G5S34_RS21620 4765030..4765770 + 741 WP_006461686.1 LPS export ABC transporter ATP-binding protein -
G5S34_RS21625 4765838..4767328 + 1491 WP_102663446.1 RNA polymerase factor sigma-54 -
G5S34_RS21630 4767487..4767849 + 363 WP_006461684.1 ribosome-associated translation inhibitor RaiA -
G5S34_RS21635 4768222..4768533 + 312 WP_006461683.1 Grx4 family monothiol glutaredoxin -
G5S34_RS21640 4768569..4769171 + 603 WP_182993023.1 UbiX family flavin prenyltransferase -
G5S34_RS21645 4769247..4769528 + 282 WP_182993024.1 type II toxin-antitoxin system HigB family toxin Toxin
G5S34_RS21650 4769516..4769941 + 426 WP_182993025.1 transcriptional regulator Antitoxin
G5S34_RS21655 4770028..4770786 - 759 WP_006461681.1 SDR family oxidoreductase -
G5S34_RS21660 4770953..4773634 - 2682 WP_182993026.1 alpha-ketoglutarate dehydrogenase -
G5S34_RS21665 4773948..4774427 + 480 WP_006461679.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(87-139)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10884.56 Da        Isoelectric Point: 10.3380

>T150606 WP_182993024.1 NZ_CP049139:4769247-4769528 [Herbaspirillum frisingense]
MRVISNKALADFALRHPQAATPLQAWRKIIESRSFDHFAELKKAFNAIDKAGDFIIFDVGGNKYRIITLVNFASQKLYIR
EVFTHREYDQWKP

Download         Length: 282 bp

>T150606 NZ_CP064831:c935954-935751 [Morganella morganii subsp. morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAAAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15585.71 Da        Isoelectric Point: 4.4954

>AT150606 WP_182993025.1 NZ_CP049139:4769516-4769941 [Herbaspirillum frisingense]
MEALIEKHVMDDITSHFAALSSLIPLRPIRSDDDYDRAVTTLNQLLDAGAGNEKHPLADLVDTLGSLIAEYDDKYFPLQQ
VSPVDVLQFLMEQHQLTQSDLPEIGSQGVVSEILRGKRELNLRQVKALAQRFGVGASVFIG

Download         Length: 426 bp

>AT150606 NZ_CP064831:c936377-936018 [Morganella morganii subsp. morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTCGTCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References