Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3684744..3685355 Replicon chromosome
Accession NZ_CP049139
Organism Herbaspirillum frisingense strain IAC152

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag G5S34_RS16705 Protein ID WP_182992439.1
Coordinates 3684744..3685031 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G5S34_RS16710 Protein ID WP_102664296.1
Coordinates 3685044..3685355 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S34_RS16690 3681345..3682418 + 1074 WP_182994974.1 alkene reductase -
G5S34_RS16695 3682676..3683443 + 768 WP_182992437.1 MipA/OmpV family protein -
G5S34_RS16700 3683914..3684486 + 573 WP_182992438.1 FxDxF family PEP-CTERM protein -
G5S34_RS16705 3684744..3685031 + 288 WP_182992439.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5S34_RS16710 3685044..3685355 + 312 WP_102664296.1 HigA family addiction module antidote protein Antitoxin
G5S34_RS16715 3685540..3686307 + 768 WP_182992440.1 exodeoxyribonuclease III -
G5S34_RS16720 3686346..3686618 - 273 WP_102664331.1 hypothetical protein -
G5S34_RS16725 3686618..3687121 - 504 WP_006712791.1 GNAT family N-acetyltransferase -
G5S34_RS16730 3687228..3689165 - 1938 WP_182992441.1 propionate--CoA ligase -
G5S34_RS16735 3689462..3689890 - 429 WP_006712794.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-85)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10764.20 Da        Isoelectric Point: 9.1805

>T150605 WP_182992439.1 NZ_CP049139:3684744-3685031 [Herbaspirillum frisingense]
MILSFRCQDTEALFHGRAVARFSNFRKVAERKLQMLDSAATLDYLRSPPGNRLEALSGNRAGQHSIRINSQYRICFVWHD
QGAVGAANVEIVDYH

Download         Length: 288 bp

>T150605 NZ_CP064830:c910248-910045 [Morganella morganii subsp. morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11327.07 Da        Isoelectric Point: 5.1548

>AT150605 WP_102664296.1 NZ_CP049139:3685044-3685355 [Herbaspirillum frisingense]
MNAPANGMRPIHPGEILREEYLAELNMSGNALAKALRVDAPRISAILREERAVTIDTALRLARFFGGDAQSWLNLQLAYD
LKMAEIELAGRIAEEVQPLARAA

Download         Length: 312 bp

>AT150605 NZ_CP064830:c910671-910312 [Morganella morganii subsp. morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTCGTCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References