Detailed information of TA system TA150575

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 3879311..3879723
• Replicon: chromosome
• Accession: NZ_CP049112
• Organism: Escherichia coli strain WF5-5-T2

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: G6R06_RS18990
• Protein ID: WP_000132601.1
• Coordinates: 3879382..3879723 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	3879311..3879387 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6R06_RS18980 (3876174)	3876174..3877763	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
G6R06_RS18985 (3877760)	3877760..3879154	+	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
- (3879311)	3879311..3879387	-	77	NuclAT_14	-	Antitoxin
- (3879311)	3879311..3879387	-	77	NuclAT_14	-	Antitoxin
- (3879311)	3879311..3879387	-	77	NuclAT_14	-	Antitoxin
- (3879311)	3879311..3879387	-	77	NuclAT_14	-	Antitoxin
- (3879311)	3879311..3879387	-	77	NuclAT_15	-	Antitoxin
- (3879311)	3879311..3879387	-	77	NuclAT_15	-	Antitoxin
- (3879311)	3879311..3879387	-	77	NuclAT_15	-	Antitoxin
- (3879311)	3879311..3879387	-	77	NuclAT_15	-	Antitoxin
G6R06_RS18990 (3879382)	3879382..3879723	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
G6R06_RS18995 (3879885)	3879885..3881264	+	1380	Protein_3708	5-methylcytosine-specific restriction endonuclease subunit McrB	-
G6R06_RS19000 (3881264)	3881264..3882310	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T150575 WP_000132601.1 NZ_CP049112:3879382-3879723 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T150575 NZ_CP064825:1140376-1140750 [Escherichia coli UTI89]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT150575 NZ_CP049112:c3879387-3879311 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin