Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 333983..334710 | Replicon | chromosome |
Accession | NZ_CP049112 | ||
Organism | Escherichia coli strain WF5-5-T2 |
Toxin (Protein)
Gene name | higB | Uniprot ID | U9ZMR4 |
Locus tag | G6R06_RS01560 | Protein ID | WP_000550189.1 |
Coordinates | 334396..334710 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | G6R06_RS01555 | Protein ID | WP_000560266.1 |
Coordinates | 333983..334399 (-) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
G6R06_RS01545 (329243) | 329243..331594 | + | 2352 | WP_000695487.1 | alpha-glucosidase | - |
G6R06_RS01550 (331920) | 331920..333938 | + | 2019 | WP_000121433.1 | NADPH-dependent 2,4-dienoyl-CoA reductase | - |
G6R06_RS01555 (333983) | 333983..334399 | - | 417 | WP_000560266.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
G6R06_RS01560 (334396) | 334396..334710 | - | 315 | WP_000550189.1 | type II toxin-antitoxin system toxin HigB | Toxin |
G6R06_RS01565 (334994) | 334994..336130 | - | 1137 | WP_000018695.1 | 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG | - |
G6R06_RS01570 (336215) | 336215..336718 | + | 504 | WP_001333820.1 | M48 family metallopeptidase | - |
G6R06_RS01575 (336795) | 336795..337487 | + | 693 | WP_000942548.1 | vancomycin high temperature exclusion protein | - |
G6R06_RS01580 (337566) | 337566..338552 | + | 987 | WP_000617698.1 | Gfo/Idh/MocA family oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12103.10 Da Isoelectric Point: 10.0409
>T150552 WP_000550189.1 NZ_CP049112:c334710-334396 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
Download Length: 315 bp
>T150552 NZ_CP064784:c3808791-3808438 [Klebsiella sp. BDA134-6]
GTGTGGATGATTAAAACAACGGATACGTTTGAGCGCTGGTTTACCTCGCTCAACGATACCGATAGGGCCAGCGTGCTTGC
AGCGCTGTTGGTCCTGCGAGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGCTCAGAGGCTCCCGCTACAGCA
ACATGAAAGAGTTGCGTATTCAGAGCCGGGGCGAGCCGATACGGGCATTTTTCGCTTTTGACCCGGCCCGTACCGGTATT
GTGCTTTGCGCCGGAAATAAGGTCAGCAATGAAAAACGTTTTTACGATGAGATTCTCCCGGTGGCTGACCGGGAATATAC
CAACTGGCTGAACACATTAAATGAGAAGGAGTAA
GTGTGGATGATTAAAACAACGGATACGTTTGAGCGCTGGTTTACCTCGCTCAACGATACCGATAGGGCCAGCGTGCTTGC
AGCGCTGTTGGTCCTGCGAGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGCTCAGAGGCTCCCGCTACAGCA
ACATGAAAGAGTTGCGTATTCAGAGCCGGGGCGAGCCGATACGGGCATTTTTCGCTTTTGACCCGGCCCGTACCGGTATT
GTGCTTTGCGCCGGAAATAAGGTCAGCAATGAAAAACGTTTTTACGATGAGATTCTCCCGGTGGCTGACCGGGAATATAC
CAACTGGCTGAACACATTAAATGAGAAGGAGTAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 14995.42 Da Isoelectric Point: 4.4547
>AT150552 WP_000560266.1 NZ_CP049112:c334399-333983 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
Download Length: 417 bp
>AT150552 NZ_CP064784:c3808433-3808131 [Klebsiella sp. BDA134-6]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAACCTGAAGTTGTGGCCGAAGCCGAGGCTATGGCTAAGGATAT
TTTGCTCAATATTCATCTTGCTGAGTTGCGTGAGAGGGTGCAGAAAACGCAGGTGGAAATGGCGCAGGAATTAGGTATCA
AGCAGCCTACCGTCGCGGGAATGGAAAAACCGGGCCGCGACCTGAAGCTCTCCACGCTCAAACGTTACGTTGAAGCGGCG
GGCGGTAAGCTAAGCCTCAATGTTGAGCTGCCGGATGGGTCGCATTACGGGTTTGTACTGTAA
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAACCTGAAGTTGTGGCCGAAGCCGAGGCTATGGCTAAGGATAT
TTTGCTCAATATTCATCTTGCTGAGTTGCGTGAGAGGGTGCAGAAAACGCAGGTGGAAATGGCGCAGGAATTAGGTATCA
AGCAGCCTACCGTCGCGGGAATGGAAAAACCGGGCCGCGACCTGAAGCTCTCCACGCTCAAACGTTACGTTGAAGCGGCG
GGCGGTAAGCTAAGCCTCAATGTTGAGCTGCCGGATGGGTCGCATTACGGGTTTGTACTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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