Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 268207..268900 Replicon chromosome
Accession NZ_CP049112
Organism Escherichia coli strain WF5-5-T2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag G6R06_RS01250 Protein ID WP_000415584.1
Coordinates 268604..268900 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag G6R06_RS01245 Protein ID WP_000650107.1
Coordinates 268207..268602 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6R06_RS01235 (264071) 264071..266329 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
G6R06_RS01240 (266467) 266467..268074 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
G6R06_RS01245 (268207) 268207..268602 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
G6R06_RS01250 (268604) 268604..268900 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
G6R06_RS01255 (269105) 269105..269587 - 483 WP_000183505.1 GyrI-like domain-containing protein -
G6R06_RS01260 (269640) 269640..270032 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
G6R06_RS01265 (270184) 270184..270843 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
G6R06_RS01270 (270840) 270840..272189 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
G6R06_RS01275 (272235) 272235..272567 - 333 WP_000917684.1 DUF2645 family protein -
G6R06_RS01280 (272886) 272886..273467 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
G6R06_RS01285 (273498) 273498..273812 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T150551 WP_000415584.1 NZ_CP049112:c268900-268604 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T150551 NZ_CP064784:c3792716-3792384 [Klebsiella sp. BDA134-6]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCCACCAGCGGCCATGAACAAAGCGGAAAACGTCCGGTACTCAT
CGTGTCGAAGGCATCATTTAACAAGCTGACCCAGCTACCCGTTATTGTTCCCGTCACCAGCGGCGGAAACTTTGCTCGCG
AAGCAGGTTTTACCGTCTCACTGGACGGCGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAGCCCAGAACTATT
GATATGGGAGCCCGGAGCGGTAAGCGACTGGAACGCATACCCGACGCTGTTGTGAATGAAGTGCTGGCCCGACTGGAGGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT150551 WP_000650107.1 NZ_CP049112:c268602-268207 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT150551 NZ_CP064784:c3792974-3792717 [Klebsiella sp. BDA134-6]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCGTCATGCTGGCAGTTCCCCCCGCCGTGCTGAAAACGCTGGGGCT
GTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGGCTGCCTGGTTATTGAACCTCAAAAACGTCCCCGCTATTCGC
TCGAAGAACTGCTGGCGCAGTGCGATCCGCATGCTGAAATAAGCGAAGAGAGTCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References