Detailed information of TA system TA150516

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 183527..183749
• Replicon: chromosome
• Accession: NZ_CP049110
• Organism: Escherichia coli strain WF5-5-T1

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: G5631_RS00885
• Protein ID: WP_000141634.1
• Coordinates: 183642..183749 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	183527..183593 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5631_RS00865	178969..179870	+	902	Protein_169	dipeptide ABC transporter permease DppC	-
G5631_RS00870	179881..180864	+	984	Protein_170	dipeptide ABC transporter ATP-binding protein	-
G5631_RS00875	180861..181865	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
G5631_RS00880	181895..183166	-	1272	WP_001295225.1	aromatic amino acid transport family protein	-
-	183527..183593	-	67	-	-	Antitoxin
G5631_RS00885	183642..183749	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
G5631_RS00890	183836..185515	-	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
G5631_RS00895	185512..185703	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
G5631_RS00900	185700..187271	-	1572	WP_001204931.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
G5631_RS00905	187544..187732	+	189	WP_072338373.1	cellulose biosynthesis protein BcsR	-
G5631_RS00910	187768..188496	+	729	WP_011310329.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T150516 WP_000141634.1 NZ_CP049110:183642-183749 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T150516 NZ_CP064768:343872-344240 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT150516 NZ_CP049110:c183593-183527 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin