Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1195913..1196563 Replicon chromosome
Accession NZ_CP049088
Organism Glaesserella parasuis strain sHPS7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G5C59_RS05790 Protein ID WP_164681650.1
Coordinates 1195913..1196251 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G5C59_RS05795 Protein ID WP_005710405.1
Coordinates 1196255..1196563 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5C59_RS05730 1191239..1191613 + 375 WP_021114543.1 cytochrome b562 family protein -
G5C59_RS05735 1191734..1192529 + 796 Protein_1139 IS256 family transposase -
G5C59_RS05740 1192517..1192783 + 267 Protein_1140 cation-transporting ATPase PacS -
G5C59_RS05750 1193250..1194689 - 1440 WP_043895984.1 glutamate--tRNA ligase -
G5C59_RS05790 1195913..1196251 + 339 WP_164681650.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5C59_RS05795 1196255..1196563 + 309 WP_005710405.1 helix-turn-helix domain-containing protein Antitoxin
G5C59_RS05800 1196764..1197924 + 1161 WP_160441069.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
G5C59_RS05805 1198024..1198605 + 582 WP_164681651.1 type IV pilus biogenesis/stability protein PilW -
G5C59_RS05810 1198666..1199601 + 936 WP_005710401.1 KpsF/GutQ family sugar-phosphate isomerase -
G5C59_RS05815 1199601..1200089 + 489 WP_005710400.1 transcription elongation factor GreB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(41-86)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13260.26 Da        Isoelectric Point: 10.0084

>T150449 WP_164681650.1 NZ_CP049088:1195913-1196251 [Glaesserella parasuis]
MNVTFVELPPFEEYRKKYLDDDSFRLLQNELLKFPDKGELIQGTGGLRKLRIADIIRQKGKRGGARVIYYYYVRGKQVWL
FHAYNKNQQDDLSNEERVVLANTLSYLKSLVR

Download         Length: 339 bp

>T150449 NZ_CP064682:c1639890-1639603 [Escherichia coli K-12]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11539.61 Da        Isoelectric Point: 10.2919

>AT150449 WP_005710405.1 NZ_CP049088:1196255-1196563 [Glaesserella parasuis]
MGKLFNELMEGMQALELHLQGKITLKTTVVEVPDPIVITPEEVKAIRQKLNLSQAVFARKLHTSVRTYQGWEQGRTKPNP
QAVLLLKMVEKSPKTFEQIASI

Download         Length: 309 bp

>AT150449 NZ_CP064682:c1640129-1639890 [Escherichia coli K-12]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References