Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 491232..491793 Replicon chromosome
Accession NZ_CP049088
Organism Glaesserella parasuis strain sHPS7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G5C59_RS02430 Protein ID WP_021114871.1
Coordinates 491515..491793 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag G5C59_RS02425 Protein ID WP_005712616.1
Coordinates 491232..491504 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5C59_RS02405 487620..488138 + 519 WP_075605585.1 single-stranded DNA-binding protein -
G5C59_RS02410 488344..489558 + 1215 WP_164681594.1 ATP-binding protein -
G5C59_RS02415 489630..489938 - 309 Protein_465 DUF853 family protein -
G5C59_RS02420 489948..491168 - 1221 WP_005712618.1 ATP-dependent RNA helicase RhlB -
G5C59_RS02425 491232..491504 - 273 WP_005712616.1 HigA family addiction module antidote protein Antitoxin
G5C59_RS02430 491515..491793 - 279 WP_021114871.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5C59_RS02435 491940..492950 + 1011 WP_164681595.1 ornithine carbamoyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10273.66 Da        Isoelectric Point: 9.6922

>T150445 WP_021114871.1 NZ_CP049088:c491793-491515 [Glaesserella parasuis]
MIISFKHKGLKLFFETGSTAGIQANHASKLAFQLATLNQAKSALDMNAPSWNLHQLQGNLAGHCSIKVSGNWRLTFKFQN
SHAEVVDYQDYH

Download         Length: 279 bp

>T150445 NZ_CP064682:c1265801-1265694 [Escherichia coli K-12]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10314.06 Da        Isoelectric Point: 9.8982

>AT150445 WP_005712616.1 NZ_CP049088:c491504-491232 [Glaesserella parasuis]
MKMYNPAHPGLILREYIEGYNVTEVAKRLGVTRVTLSRILNGKAAISPEMALRLSQLLKTSPELWLGLQSQYDLWQLEQR
PSFNIQPLFA

Download         Length: 273 bp

>AT150445 NZ_CP064682:1265848-1265914 [Escherichia coli K-12]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References