Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 48173..48816 Replicon chromosome
Accession NZ_CP049088
Organism Glaesserella parasuis strain sHPS7

Toxin (Protein)


Gene name higB Uniprot ID U4SMB1
Locus tag G5C59_RS00330 Protein ID WP_005714197.1
Coordinates 48472..48816 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G5C59_RS00325 Protein ID WP_016527809.1
Coordinates 48173..48469 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5C59_RS00300 43392..44600 - 1209 Protein_56 IS256 family transposase -
G5C59_RS00305 44646..45362 - 717 WP_164681544.1 hypothetical protein -
G5C59_RS00310 45641..46288 - 648 WP_016527812.1 hypothetical protein -
G5C59_RS00315 46305..47078 - 774 WP_035519505.1 PD-(D/E)XK nuclease family protein -
G5C59_RS00320 47154..48116 - 963 WP_164681545.1 WYL domain-containing protein -
G5C59_RS00325 48173..48469 - 297 WP_016527809.1 helix-turn-helix domain-containing protein Antitoxin
G5C59_RS00330 48472..48816 - 345 WP_005714197.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5C59_RS00335 48958..50055 - 1098 WP_164681546.1 ISAs1 family transposase -
G5C59_RS00340 50246..52225 + 1980 WP_021118195.1 exoribonuclease II -
G5C59_RS00345 52336..53427 + 1092 WP_021118196.1 murein transglycosylase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 43830..44600 770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(52-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13263.22 Da        Isoelectric Point: 5.9233

>T150443 WP_005714197.1 NZ_CP049088:c48816-48472 [Glaesserella parasuis]
METEEYLTFIETKVFEEDRKALMSDDEYQKFQAYLLESHELGDFIQNTGGCQKIRWKLESNNKGKSGGVRVIYYVVTKQG
KLLLMMMYAKSKQDNMSDKQKAMLKAVVSQLSEE

Download         Length: 345 bp

>T150443 NZ_CP064682:c1264731-1264624 [Escherichia coli K-12]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11196.11 Da        Isoelectric Point: 8.8246

>AT150443 WP_016527809.1 NZ_CP049088:c48469-48173 [Glaesserella parasuis]
MEKELFERLMESAREMVAIEKGEIEVPPHRIHIHKIPNVKAIRTQHQMKQAEFASLLGVSQNLVQSWEIGRRTPNGAARK
LLAIIEQQPELIPVLQGL

Download         Length: 297 bp

>AT150443 NZ_CP064682:1264779-1264845 [Escherichia coli K-12]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U4SMB1

Antitoxin

Source ID Structure

References