Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 600949..601748 Replicon chromosome
Accession NZ_CP049085
Organism Escherichia coli strain p4A

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag G6P91_RS02920 Protein ID WP_000347251.1
Coordinates 600949..601413 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag G6P91_RS02925 Protein ID WP_001296435.1
Coordinates 601413..601748 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6P91_RS02890 595950..596384 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
G6P91_RS02895 596402..597280 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
G6P91_RS02900 597270..598049 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
G6P91_RS02905 598060..598533 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
G6P91_RS02910 598556..599836 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
G6P91_RS02915 600085..600894 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
G6P91_RS02920 600949..601413 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
G6P91_RS02925 601413..601748 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
G6P91_RS02930 601897..603468 - 1572 WP_001273763.1 galactarate dehydratase -
G6P91_RS02935 603843..605177 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
G6P91_RS02940 605193..605963 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T150417 WP_000347251.1 NZ_CP049085:c601413-600949 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T150417 NZ_CP064681:c1265266-1265159 [Escherichia coli K-12]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT150417 WP_001296435.1 NZ_CP049085:c601748-601413 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT150417 NZ_CP064681:1265313-1265379 [Escherichia coli K-12]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References