Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2954751..2955253 Replicon chromosome
Accession NZ_CP049081
Organism Escherichia coli strain p10A

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7I6H4L3
Locus tag G6P90_RS14565 Protein ID WP_000767831.1
Coordinates 2954751..2955005 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag G6P90_RS14570 Protein ID WP_001259255.1
Coordinates 2955002..2955253 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6P90_RS14535 2949766..2949993 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
G6P90_RS14540 2950007..2951065 - 1059 WP_000492321.1 transport protein YeeE -
G6P90_RS14545 2951244..2952602 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
G6P90_RS14550 2952592..2952654 - 63 WP_010723108.1 membrane protein YoeI -
G6P90_RS14555 2952869..2953798 - 930 WP_024195433.1 LysR family transcriptional regulator -
G6P90_RS14560 2953844..2954668 - 825 WP_000754737.1 SDR family oxidoreductase -
G6P90_RS14565 2954751..2955005 - 255 WP_000767831.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
G6P90_RS14570 2955002..2955253 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
G6P90_RS14575 2955537..2955587 + 51 WP_001364200.1 his operon leader peptide -
G6P90_RS14580 2955733..2956632 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
G6P90_RS14585 2956638..2957942 + 1305 WP_001446927.1 histidinol dehydrogenase -
G6P90_RS14590 2957939..2959009 + 1071 WP_000108945.1 histidinol-phosphate transaminase -
G6P90_RS14595 2959009..2960076 + 1068 WP_000080090.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10231.67 Da        Isoelectric Point: 8.8202

>T150403 WP_000767831.1 NZ_CP049081:c2955005-2954751 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY

Download         Length: 255 bp

>T150403 NZ_CP064680:c3034180-3033773 [Escherichia coli K-12]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT150403 WP_001259255.1 NZ_CP049081:c2955253-2955002 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT150403 NZ_CP064680:c3034427-3034161 [Escherichia coli K-12]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H4L3

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References