Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 697729..698422 Replicon chromosome
Accession NZ_CP049081
Organism Escherichia coli strain p10A

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag G6P90_RS03405 Protein ID WP_000415585.1
Coordinates 697729..698025 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag G6P90_RS03410 Protein ID WP_000650107.1
Coordinates 698027..698422 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6P90_RS03375 692863..694055 + 1193 Protein_654 Hcp family type VI secretion system effector -
G6P90_RS03380 694062..694394 + 333 WP_000914690.1 DUF2645 family protein -
G6P90_RS03385 694440..695789 - 1350 WP_000673358.1 two-component system sensor histidine kinase QseC -
G6P90_RS03390 695786..696445 - 660 WP_001221502.1 two-component system response regulator QseB -
G6P90_RS03395 696597..696989 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
G6P90_RS03400 697042..697524 + 483 WP_000183505.1 transcriptional regulator -
G6P90_RS03405 697729..698025 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
G6P90_RS03410 698027..698422 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
G6P90_RS03415 698555..700162 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
G6P90_RS03420 700300..702558 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 680735..702558 21823


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T150390 WP_000415585.1 NZ_CP049081:697729-698025 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T150390 NZ_CP064680:c1265266-1265159 [Escherichia coli K-12]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT150390 WP_000650107.1 NZ_CP049081:698027-698422 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT150390 NZ_CP064680:1265313-1265379 [Escherichia coli K-12]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References