Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2207932..2208528 Replicon chromosome
Accession NZ_CP049055
Organism Candidatus Kuenenia stuttgartiensis strain CSTR1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag KsCSTR_RS09955 Protein ID WP_099326908.1
Coordinates 2207932..2208213 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KsCSTR_RS09960 Protein ID WP_099326907.1
Coordinates 2208223..2208528 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KsCSTR_RS09925 2203403..2203765 + 363 WP_099326912.1 hypothetical protein -
KsCSTR_RS19660 2203722..2203922 + 201 WP_197705290.1 hypothetical protein -
KsCSTR_RS19665 2203883..2204128 + 246 WP_197705289.1 hypothetical protein -
KsCSTR_RS19670 2204095..2204532 + 438 WP_197705288.1 AAA family ATPase -
KsCSTR_RS19675 2204465..2205157 + 693 WP_197705287.1 AAA family ATPase -
KsCSTR_RS09935 2205186..2205767 + 582 WP_157820798.1 HdeD family acid-resistance protein -
KsCSTR_RS09940 2206500..2206658 - 159 WP_164994262.1 hypothetical protein -
KsCSTR_RS09945 2206585..2206776 - 192 WP_157820797.1 phage integrase N-terminal SAM-like domain-containing protein -
KsCSTR_RS09950 2207000..2207815 + 816 WP_157820795.1 hypothetical protein -
KsCSTR_RS09955 2207932..2208213 + 282 WP_099326908.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KsCSTR_RS09960 2208223..2208528 + 306 WP_099326907.1 HigA family addiction module antidote protein Antitoxin
KsCSTR_RS09965 2208796..2209032 - 237 WP_157820793.1 phage integrase N-terminal SAM-like domain-containing protein -
KsCSTR_RS09970 2209029..2209160 - 132 WP_157820792.1 phage integrase N-terminal SAM-like domain-containing protein -
KsCSTR_RS09975 2209307..2210275 + 969 WP_099326906.1 hypothetical protein -
KsCSTR_RS09980 2210345..2211034 + 690 WP_099326905.1 tetratricopeptide repeat protein -
KsCSTR_RS09985 2211280..2211489 + 210 WP_157820789.1 hypothetical protein -
KsCSTR_RS09990 2211491..2211760 + 270 WP_099326903.1 DUF2283 domain-containing protein -
KsCSTR_RS09995 2211897..2212541 - 645 WP_099326902.1 endonuclease III domain-containing protein -
KsCSTR_RS10000 2212534..2213505 - 972 WP_099326901.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11173.90 Da        Isoelectric Point: 9.5803

>T150347 WP_099326908.1 NZ_CP049055:2207932-2208213 [Candidatus Kuenenia stuttgartiensis]
MIKNFACKETEKIFNRRISLKLPRDIQKTARRKLEILEGAEILMDLRIPPNNHLEKLSKDRNGQYSIRINDQWRICFEWR
GGDAYNVEIVDYH

Download         Length: 282 bp

>T150347 NZ_CP064678:2770812-2771141 [Escherichia coli K-12]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11871.81 Da        Isoelectric Point: 9.5337

>AT150347 WP_099326907.1 NZ_CP049055:2208223-2208528 [Candidatus Kuenenia stuttgartiensis]
MAKKILDPIHPGEILMEEFLKPMGISQYRLAKDINVPARRINEIVQGKRSVTPDTALRLSRFFGLSERFWINLQARYDLE
IEKDRLKNRLDEEVHVYTSAM

Download         Length: 306 bp

>AT150347 NZ_CP064678:2770474-2770791 [Escherichia coli K-12]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References