Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1818411..1818913 | Replicon | chromosome |
| Accession | NZ_CP048915 | ||
| Organism | Escherichia coli strain E2 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | G5S48_RS08635 | Protein ID | WP_000767829.1 |
| Coordinates | 1818659..1818913 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | G5S48_RS08630 | Protein ID | WP_001259255.1 |
| Coordinates | 1818411..1818662 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G5S48_RS08605 (1813588) | 1813588..1814655 | - | 1068 | WP_000080060.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| G5S48_RS08610 (1814655) | 1814655..1815725 | - | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
| G5S48_RS08615 (1815722) | 1815722..1817026 | - | 1305 | WP_001317939.1 | histidinol dehydrogenase | - |
| G5S48_RS08620 (1817032) | 1817032..1817931 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| G5S48_RS08625 (1818077) | 1818077..1818127 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| G5S48_RS08630 (1818411) | 1818411..1818662 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| G5S48_RS08635 (1818659) | 1818659..1818913 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| G5S48_RS08640 (1818996) | 1818996..1819820 | + | 825 | WP_000754758.1 | SDR family oxidoreductase | - |
| G5S48_RS08645 (1819866) | 1819866..1820795 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| G5S48_RS08650 (1821010) | 1821010..1821072 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| G5S48_RS08655 (1821062) | 1821062..1822420 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| G5S48_RS08660 (1822599) | 1822599..1823657 | + | 1059 | WP_000492346.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| G5S48_RS08665 (1823671) | 1823671..1823898 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T150177 WP_000767829.1 NZ_CP048915:1818659-1818913 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T150177 NZ_CP064403:c1407916-1407734 [Pseudomonas aeruginosa]
ATGAAGTTCAGCGAATTCAGACGATGGTTGAAGGCCCAAGGGGTGACCTTCGAAGCCGGCAAGGGAAGCCACTTCAAGAT
CACCGCCCCGAACGGCAAACAGACCACCTTCGCGGACCACGGAGCTAAGGAAATGCCAGAACCGACCCGCAAGGCGATCA
TCAAGCAACTGGGGCTCAAATGA
ATGAAGTTCAGCGAATTCAGACGATGGTTGAAGGCCCAAGGGGTGACCTTCGAAGCCGGCAAGGGAAGCCACTTCAAGAT
CACCGCCCCGAACGGCAAACAGACCACCTTCGCGGACCACGGAGCTAAGGAAATGCCAGAACCGACCCGCAAGGCGATCA
TCAAGCAACTGGGGCTCAAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT150177 WP_001259255.1 NZ_CP048915:1818411-1818662 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT150177 NZ_CP064403:c1407687-1407259 [Pseudomonas aeruginosa]
ATGTACGACTATGCAATCCGTTTCGAACAGGACGATAGCGCTCCTGGCGTCGCCGTTTTCTGTCGAGACCTTCCAGAACT
GAACAGCTACGGCGACGATAAGGCCCATGCAATCAGCGAGGCAGTTGACGCCATCGAGTCAACCCTCTCGCTGTACGTTG
ATCAGCGCCGAGAAATCCCCGCAGCCAGCCAGGCACAACCAGGCGAGCGCGTTATCCATCTGCCGGCGGTTACCGTTGCG
AAGGTCGCGCTCTGGAACGAAATGATCCGTCGAGATATGCGAAAAGCTGACCTCTGCCGGCTCCTCGGGATCGCGCAGAT
CCAGGGTGACAGGCTCGTCGACTTCCTCCACAACACCAAGATGGAAGCCATGGAGAACGCGCTATCCGCCCTCGGCCTCC
GCCTCTCAGTGAATATCGAGGCGGCATGA
ATGTACGACTATGCAATCCGTTTCGAACAGGACGATAGCGCTCCTGGCGTCGCCGTTTTCTGTCGAGACCTTCCAGAACT
GAACAGCTACGGCGACGATAAGGCCCATGCAATCAGCGAGGCAGTTGACGCCATCGAGTCAACCCTCTCGCTGTACGTTG
ATCAGCGCCGAGAAATCCCCGCAGCCAGCCAGGCACAACCAGGCGAGCGCGTTATCCATCTGCCGGCGGTTACCGTTGCG
AAGGTCGCGCTCTGGAACGAAATGATCCGTCGAGATATGCGAAAAGCTGACCTCTGCCGGCTCCTCGGGATCGCGCAGAT
CCAGGGTGACAGGCTCGTCGACTTCCTCCACAACACCAAGATGGAAGCCATGGAGAACGCGCTATCCGCCCTCGGCCTCC
GCCTCTCAGTGAATATCGAGGCGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|