Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 743096..743789 Replicon chromosome
Accession NZ_CP048915
Organism Escherichia coli strain E2

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag G5S48_RS03605 Protein ID WP_000415585.1
Coordinates 743096..743392 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag G5S48_RS03610 Protein ID WP_000650107.1
Coordinates 743394..743789 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S48_RS24265 (738230) 738230..738709 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
G5S48_RS24270 (738712) 738712..739422 + 711 WP_000834030.1 hypothetical protein -
G5S48_RS03580 (739429) 739429..739761 + 333 WP_000914690.1 DUF2645 family protein -
G5S48_RS03585 (739807) 739807..741156 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
G5S48_RS03590 (741153) 741153..741812 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
G5S48_RS03595 (741964) 741964..742356 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
G5S48_RS03600 (742409) 742409..742891 + 483 WP_000183505.1 GyrI-like domain-containing protein -
G5S48_RS03605 (743096) 743096..743392 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
G5S48_RS03610 (743394) 743394..743789 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
G5S48_RS03615 (743922) 743922..745529 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
G5S48_RS03620 (745667) 745667..747925 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T150172 WP_000415585.1 NZ_CP048915:743096-743392 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T150172 NZ_CP064401:c5703400-5703110 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT150172 WP_000650107.1 NZ_CP048915:743394-743789 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT150172 NZ_CP064401:c5703696-5703397 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References