Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 5905124..5905635 Replicon chromosome
Accession NZ_CP048882
Organism Streptomyces bathyalis strain ASO4wet

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag G4Z16_RS25570 Protein ID WP_197352998.1
Coordinates 5905124..5905378 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag G4Z16_RS25575 Protein ID WP_197352999.1
Coordinates 5905375..5905635 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4Z16_RS25545 5901179..5901547 + 369 WP_197352994.1 VOC family protein -
G4Z16_RS25550 5901870..5902028 - 159 Protein_5045 DUF2188 domain-containing protein -
G4Z16_RS25555 5902332..5902538 + 207 WP_197352995.1 hypothetical protein -
G4Z16_RS25560 5902535..5903200 - 666 WP_197352996.1 hypothetical protein -
G4Z16_RS25565 5903774..5904979 - 1206 WP_197352997.1 cysteine desulfurase-like protein -
G4Z16_RS25570 5905124..5905378 - 255 WP_197352998.1 Txe/YoeB family addiction module toxin Toxin
G4Z16_RS25575 5905375..5905635 - 261 WP_197352999.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G4Z16_RS25580 5905739..5906416 + 678 WP_197354904.1 peroxiredoxin -
G4Z16_RS25585 5906550..5908769 + 2220 WP_197353000.1 NADP-dependent isocitrate dehydrogenase -
G4Z16_RS25590 5909096..5909812 + 717 WP_197353001.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10174.51 Da        Isoelectric Point: 10.0152

>T150147 WP_197352998.1 NZ_CP048882:c5905378-5905124 [Streptomyces bathyalis]
VKTVFTEHGWTDYVHWPETDRRMTKRINRLIEERKRDPFAGIGKPEPLKGDLSGYWSRRIDDERRLVYRARGDELIVAQA
RYHY

Download         Length: 255 bp

>T150147 NZ_CP064395:c5652352-5652053 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9640.57 Da        Isoelectric Point: 4.2932

>AT150147 WP_197352999.1 NZ_CP048882:c5905635-5905375 [Streptomyces bathyalis]
VSITASEARKNLFPLIEQVNNDRAPVHITSRNGNAVLLSEEDYSSWQETIYLLRSPANARRLSESIAEAEAGRTEPRELI
EVDDSE

Download         Length: 261 bp

>AT150147 NZ_CP064395:c5652056-5651766 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References