Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 75751..76487 Replicon plasmid pC
Accession NZ_CP048881
Organism Spartinivicinus ruber strain S2-4-1H

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G4Y78_RS30550 Protein ID WP_163837002.1
Coordinates 75751..76062 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G4Y78_RS30555 Protein ID WP_163837003.1
Coordinates 76059..76487 (+) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4Y78_RS30525 71884..72675 - 792 WP_163836998.1 hypothetical protein -
G4Y78_RS30530 73026..73289 - 264 WP_163837015.1 excalibur calcium-binding domain-containing protein -
G4Y78_RS30535 73733..74653 + 921 WP_163836999.1 hypothetical protein -
G4Y78_RS30540 74806..75216 - 411 WP_163837000.1 hypothetical protein -
G4Y78_RS30545 75258..75545 - 288 WP_163837001.1 hypothetical protein -
G4Y78_RS30550 75751..76062 + 312 WP_163837002.1 type II toxin-antitoxin system HigB family toxin Toxin
G4Y78_RS30555 76059..76487 + 429 WP_163837003.1 transcriptional regulator Antitoxin
G4Y78_RS30560 76501..76809 + 309 WP_163837004.1 helix-turn-helix domain-containing protein -
G4Y78_RS30565 76955..77194 + 240 WP_163837005.1 hypothetical protein -
G4Y78_RS30570 77218..78330 - 1113 WP_163837006.1 YrzE family protein -
G4Y78_RS30575 78496..78849 - 354 WP_163837007.1 hypothetical protein -
G4Y78_RS30580 78833..79501 - 669 WP_163837008.1 AAA family ATPase -
G4Y78_RS30585 79804..80097 + 294 WP_163837009.1 MarR family transcriptional regulator -
G4Y78_RS30590 80219..80920 + 702 WP_163837010.1 transporter substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..82464 82464


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Antitoxin HigA

(18-142)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12622.68 Da        Isoelectric Point: 10.5319

>T150146 WP_163837002.1 NZ_CP048881:75751-76062 [Spartinivicinus ruber]
MHIISKRPFNEAARKYPNERQAIMDLYRVLKRATFNSPDEMRKLFPSLDNFKYKDKWWVIDIGGNNLRLIAFIEFVQNRM
YVKHIVTHKEYDRLTQRYKRGEL

Download         Length: 312 bp

>T150146 NZ_CP064395:c5652056-5651766 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15982.20 Da        Isoelectric Point: 4.4783

>AT150146 WP_163837003.1 NZ_CP048881:76059-76487 [Spartinivicinus ruber]
MINPEVKNAFESFASVAAPYLHIVDEEHYEDALALVEELLEEVSDNPDDPKNTLIDMLSKSIGEYEDKDEALAKFEKKAH
KGPADIAMLRLIIDQHQLTLSDFPEIGDKTLMSKILKGERNLTKQHIIALSNRFGISPGLFF

Download         Length: 429 bp

>AT150146 NZ_CP064395:c5652352-5652053 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References