Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 98651..99337 Replicon plasmid pB
Accession NZ_CP048880
Organism Spartinivicinus ruber strain S2-4-1H

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G4Y78_RS30060 Protein ID WP_163836090.1
Coordinates 98987..99337 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G4Y78_RS30055 Protein ID WP_163836089.1
Coordinates 98651..98971 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4Y78_RS30015 94063..94278 - 216 WP_163836901.1 toxin-antitoxin system HicB family antitoxin -
G4Y78_RS30020 94250..94699 - 450 WP_163836902.1 putative toxin-antitoxin system toxin component, PIN family -
G4Y78_RS30025 95010..95558 - 549 WP_163836903.1 hypothetical protein -
G4Y78_RS30030 95820..96242 - 423 WP_163836904.1 hypothetical protein -
G4Y78_RS30035 96900..97088 + 189 WP_163836905.1 hypothetical protein -
G4Y78_RS30040 97195..97803 + 609 WP_163836906.1 AbiEi antitoxin N-terminal domain-containing protein -
G4Y78_RS30045 97800..98006 + 207 Protein_125 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
G4Y78_RS30050 98008..98343 + 336 WP_163836907.1 DDE-type integrase/transposase/recombinase -
G4Y78_RS30055 98651..98971 - 321 WP_163836089.1 XRE family transcriptional regulator Antitoxin
G4Y78_RS30060 98987..99337 - 351 WP_163836090.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G4Y78_RS30065 99552..99743 + 192 WP_163836908.1 type II toxin-antitoxin system VapB family antitoxin -
G4Y78_RS30070 99743..100156 + 414 WP_163836909.1 PIN domain nuclease -
G4Y78_RS30075 100203..100604 - 402 WP_163836910.1 IS200/IS605 family transposase -
G4Y78_RS30080 100644..101747 + 1104 Protein_132 IS200/IS605 family element transposase accessory protein TnpB -
G4Y78_RS30085 102016..102063 + 48 WP_163836916.1 hypothetical protein -
G4Y78_RS30090 102133..102384 - 252 WP_187697957.1 tail fiber domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..102423 102423
- flank IS/Tn - - 100203..100559 356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-84)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13591.70 Da        Isoelectric Point: 7.2784

>T150144 WP_163836090.1 NZ_CP048880:c99337-98987 [Spartinivicinus ruber]
MWKVVTVDEFDQWFLGLNEAEQVSVLTVIKLLEVRGPELGRPYADTLESTKEVKNLKELRTQHQGRPYRIFFAFDPKRQA
VLLCGGDKTGDKRFYKRMIPIAEGEFLKHLEKEELH

Download         Length: 351 bp

>T150144 NZ_CP064395:c4720087-4719332 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGCTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11569.03 Da        Isoelectric Point: 4.8304

>AT150144 WP_163836089.1 NZ_CP048880:c98971-98651 [Spartinivicinus ruber]
MAKPLSELLKQVSPEVQAKASAKAAELLTEMTLAELRQSKDITQTELAEALSTTQPNIANVEKRSDVYLSTLRNYLHALG
GELEVVARFPDGSAVAINQYDNNHTT

Download         Length: 321 bp

>AT150144 NZ_CP064395:c4720590-4720222 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References