Detailed information of TA system TA150109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 5981414..5981940
• Replicon: chromosome
• Accession: NZ_CP048835
• Organism: Streptomyces sp. So13.3

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: C8250_RS27115
• Protein ID: WP_138358619.1
• Coordinates: 5981414..5981683 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: C8250_RS27120
• Protein ID: WP_138358631.1
• Coordinates: 5981680..5981940 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C8250_RS27095	5977291..5978286	+	996	WP_138358613.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
C8250_RS27100	5978345..5979082	+	738	WP_138358615.1	ROK family protein	-
C8250_RS27105	5979003..5979476	-	474	WP_138358629.1	hypothetical protein	-
C8250_RS27110	5979813..5980901	+	1089	WP_138358617.1	redox-regulated ATPase YchF	-
C8250_RS27115	5981414..5981683	-	270	WP_138358619.1	Txe/YoeB family addiction module toxin	Toxin
C8250_RS27120	5981680..5981940	-	261	WP_138358631.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
C8250_RS27125	5982261..5985440	+	3180	WP_138358621.1	DEAD/DEAH box helicase	-
C8250_RS27130	5985437..5986834	+	1398	WP_138358623.1	SWIM zinc finger family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10405.98 Da
• Isoelectric Point: 10.1371

>T150109 WP_138358619.1 NZ_CP048835:c5981683-5981414 [Streptomyces sp. So13.3]
VKVMFSTRAWEQYAQWAMIDRRSLKRINVLIADIQRNPDDGNGIGKPEMLKGALKGWCSRRITEEHRLVYRVSGDVLEIA
RVYGHYTDR

Nucleotide

• Length: 270 bp

>T150109 NZ_CP064389:672598-672960 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9456.61 Da
• Isoelectric Point: 4.2577

>AT150109 WP_138358631.1 NZ_CP048835:c5981940-5981680 [Streptomyces sp. So13.3]
MTITGTEARRDFFPLLKKVNDDHAPVRIASKQGNAVLMAESDYEAWTETMYLLGNARTAAELMESVAELDAGRGTVRDLI
DPEAAE

Nucleotide

• Length: 261 bp

>AT150109 NZ_CP064389:672431-672601 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA