Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2273896..2274590 Replicon chromosome
Accession NZ_CP048832
Organism Janthinobacterium lividum strain EIF1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G3257_RS10220 Protein ID WP_176375094.1
Coordinates 2274309..2274590 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G3257_RS10215 Protein ID WP_176375093.1
Coordinates 2273896..2274321 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3257_RS10185 2269411..2269794 - 384 WP_176375091.1 hypothetical protein -
G3257_RS10190 2269856..2270353 - 498 WP_176375092.1 phasin family protein -
G3257_RS10195 2270699..2271580 + 882 WP_077401742.1 formyltetrahydrofolate deformylase -
G3257_RS10200 2271631..2272173 + 543 WP_034786185.1 YaeQ family protein -
G3257_RS10205 2272234..2273019 - 786 WP_099387137.1 DUF2807 domain-containing protein -
G3257_RS10210 2273208..2273843 + 636 WP_034786181.1 SAM-dependent methyltransferase -
G3257_RS10215 2273896..2274321 - 426 WP_176375093.1 transcriptional regulator Antitoxin
G3257_RS10220 2274309..2274590 - 282 WP_176375094.1 type II toxin-antitoxin system HigB family toxin Toxin
G3257_RS10225 2274667..2275941 - 1275 WP_176375095.1 cytochrome c -
G3257_RS10230 2275938..2276684 - 747 WP_152615315.1 c-type cytochrome -
G3257_RS10235 2276824..2278236 + 1413 WP_099387140.1 PLP-dependent aminotransferase family protein -
G3257_RS10240 2278336..2278683 + 348 WP_034786172.1 DUF4870 domain-containing protein -
G3257_RS10245 2278705..2279139 - 435 WP_176375096.1 SMI1/KNR4 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-90)

Antitoxin

Antitoxin HigA

(26-140)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10883.70 Da        Isoelectric Point: 10.8017

>T150098 WP_176375094.1 NZ_CP048832:c2274590-2274309 [Janthinobacterium lividum]
MRIVANKALMDFARKHPLAGEPMQAWRKVIESRPFANFAVLKSTFNATDRVGDYYVFNIGGNKYRIIAAIHFNRQLLFIR
QVLTHKEYDAWKP

Download         Length: 282 bp

>T150098 NZ_CP064387:4609516-4609923 [Escherichia coli O104:H4]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15364.62 Da        Isoelectric Point: 5.1096

>AT150098 WP_176375093.1 NZ_CP048832:c2274321-2273896 [Janthinobacterium lividum]
METLMHREMITEITVHYQALSKLVPLQAIPDAAAYEQAVSVLQHLLDAGAADEQHPLAGLVDSIGRLIGDYDQEHFPPAS
VSPAATLRLLMEQHALTQSDLPEIGTQGVVSEILSSKRALNVRQIKALTQRFNVPASVFMA

Download         Length: 426 bp

>AT150098 NZ_CP064387:4609269-4609535 [Escherichia coli O104:H4]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References