Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2226819..2227512 Replicon chromosome
Accession NZ_CP048821
Organism Escherichia coli strain QEC11-421

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QE11421_RS10945 Protein ID WP_000415584.1
Coordinates 2227216..2227512 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QE11421_RS10940 Protein ID WP_000650107.1
Coordinates 2226819..2227214 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QE11421_RS10930 2222683..2224941 - 2259 WP_049253102.1 DNA topoisomerase IV subunit A -
QE11421_RS10935 2225079..2226686 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QE11421_RS10940 2226819..2227214 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QE11421_RS10945 2227216..2227512 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QE11421_RS10950 2227717..2228199 - 483 WP_000183505.1 transcriptional regulator -
QE11421_RS10955 2228252..2228644 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QE11421_RS10960 2228796..2229455 + 660 WP_001221493.1 two-component system response regulator QseB -
QE11421_RS10965 2229452..2230801 + 1350 WP_001618857.1 two-component system sensor histidine kinase QseC -
QE11421_RS10970 2230847..2231179 - 333 WP_000917684.1 DUF2645 family protein -
QE11421_RS10975 2231498..2232079 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QE11421_RS10980 2232110..2232424 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T150073 WP_000415584.1 NZ_CP048821:c2227512-2227216 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T150073 NZ_CP064385:3531288-3531575 [Salmonella enterica subsp. enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT150073 WP_000650107.1 NZ_CP048821:c2227214-2226819 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT150073 NZ_CP064385:3531562-3531864 [Salmonella enterica subsp. enterica]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References