Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-ohsC/Ldr(toxin)
Location 330169..330390 Replicon chromosome
Accession NZ_CP048821
Organism Escherichia coli strain QEC11-421

Toxin (Protein)


Gene name ldrD Uniprot ID E3PKK3
Locus tag QE11421_RS01680 Protein ID WP_000170951.1
Coordinates 330169..330276 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 330324..330390 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QE11421_RS01655 326015..327097 + 1083 WP_000804726.1 peptide chain release factor 1 -
QE11421_RS01660 327097..327930 + 834 WP_000456454.1 peptide chain release factor N(5)-glutamine methyltransferase -
QE11421_RS01665 327927..328319 + 393 WP_000200373.1 invasion regulator SirB2 -
QE11421_RS01670 328323..329132 + 810 WP_001257044.1 invasion regulator SirB1 -
QE11421_RS01675 329168..330022 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
QE11421_RS01680 330169..330276 - 108 WP_000170951.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 330324..330390 + 67 NuclAT_12 - Antitoxin
- 330324..330390 + 67 NuclAT_12 - Antitoxin
- 330324..330390 + 67 NuclAT_12 - Antitoxin
- 330324..330390 + 67 NuclAT_12 - Antitoxin
- 330324..330390 + 67 NuclAT_14 - Antitoxin
- 330324..330390 + 67 NuclAT_14 - Antitoxin
- 330324..330390 + 67 NuclAT_14 - Antitoxin
- 330324..330390 + 67 NuclAT_14 - Antitoxin
- 330324..330390 + 67 NuclAT_16 - Antitoxin
- 330324..330390 + 67 NuclAT_16 - Antitoxin
- 330324..330390 + 67 NuclAT_16 - Antitoxin
- 330324..330390 + 67 NuclAT_16 - Antitoxin
- 330324..330390 + 67 NuclAT_18 - Antitoxin
- 330324..330390 + 67 NuclAT_18 - Antitoxin
- 330324..330390 + 67 NuclAT_18 - Antitoxin
- 330324..330390 + 67 NuclAT_18 - Antitoxin
- 330324..330390 + 67 NuclAT_20 - Antitoxin
- 330324..330390 + 67 NuclAT_20 - Antitoxin
- 330324..330390 + 67 NuclAT_20 - Antitoxin
- 330324..330390 + 67 NuclAT_20 - Antitoxin
- 330324..330390 + 67 NuclAT_22 - Antitoxin
- 330324..330390 + 67 NuclAT_22 - Antitoxin
- 330324..330390 + 67 NuclAT_22 - Antitoxin
- 330324..330390 + 67 NuclAT_22 - Antitoxin
- 330326..330389 + 64 NuclAT_27 - -
- 330326..330389 + 64 NuclAT_27 - -
- 330326..330389 + 64 NuclAT_27 - -
- 330326..330389 + 64 NuclAT_27 - -
- 330326..330389 + 64 NuclAT_30 - -
- 330326..330389 + 64 NuclAT_30 - -
- 330326..330389 + 64 NuclAT_30 - -
- 330326..330389 + 64 NuclAT_30 - -
- 330326..330389 + 64 NuclAT_33 - -
- 330326..330389 + 64 NuclAT_33 - -
- 330326..330389 + 64 NuclAT_33 - -
- 330326..330389 + 64 NuclAT_33 - -
- 330326..330389 + 64 NuclAT_36 - -
- 330326..330389 + 64 NuclAT_36 - -
- 330326..330389 + 64 NuclAT_36 - -
- 330326..330389 + 64 NuclAT_36 - -
- 330326..330389 + 64 NuclAT_40 - -
- 330326..330389 + 64 NuclAT_40 - -
- 330326..330389 + 64 NuclAT_40 - -
- 330326..330389 + 64 NuclAT_40 - -
- 330326..330389 + 64 NuclAT_43 - -
- 330326..330389 + 64 NuclAT_43 - -
- 330326..330389 + 64 NuclAT_43 - -
- 330326..330389 + 64 NuclAT_43 - -
- 330326..330391 + 66 NuclAT_46 - -
- 330326..330391 + 66 NuclAT_46 - -
- 330326..330391 + 66 NuclAT_46 - -
- 330326..330391 + 66 NuclAT_46 - -
QE11421_RS01685 330704..330811 - 108 WP_000170963.1 small toxic polypeptide LdrB -
- 330859..330924 + 66 NuclAT_25 - -
- 330859..330924 + 66 NuclAT_25 - -
- 330859..330924 + 66 NuclAT_25 - -
- 330859..330924 + 66 NuclAT_25 - -
- 330859..330924 + 66 NuclAT_28 - -
- 330859..330924 + 66 NuclAT_28 - -
- 330859..330924 + 66 NuclAT_28 - -
- 330859..330924 + 66 NuclAT_28 - -
- 330859..330924 + 66 NuclAT_31 - -
- 330859..330924 + 66 NuclAT_31 - -
- 330859..330924 + 66 NuclAT_31 - -
- 330859..330924 + 66 NuclAT_31 - -
- 330859..330924 + 66 NuclAT_34 - -
- 330859..330924 + 66 NuclAT_34 - -
- 330859..330924 + 66 NuclAT_34 - -
- 330859..330924 + 66 NuclAT_34 - -
- 330859..330924 + 66 NuclAT_38 - -
- 330859..330924 + 66 NuclAT_38 - -
- 330859..330924 + 66 NuclAT_38 - -
- 330859..330924 + 66 NuclAT_38 - -
- 330859..330924 + 66 NuclAT_41 - -
- 330859..330924 + 66 NuclAT_41 - -
- 330859..330924 + 66 NuclAT_41 - -
- 330859..330924 + 66 NuclAT_41 - -
- 330859..330926 + 68 NuclAT_44 - -
- 330859..330926 + 68 NuclAT_44 - -
- 330859..330926 + 68 NuclAT_44 - -
- 330859..330926 + 68 NuclAT_44 - -
- 330860..330925 + 66 NuclAT_13 - -
- 330860..330925 + 66 NuclAT_13 - -
- 330860..330925 + 66 NuclAT_13 - -
- 330860..330925 + 66 NuclAT_13 - -
- 330860..330925 + 66 NuclAT_15 - -
- 330860..330925 + 66 NuclAT_15 - -
- 330860..330925 + 66 NuclAT_15 - -
- 330860..330925 + 66 NuclAT_15 - -
- 330860..330925 + 66 NuclAT_17 - -
- 330860..330925 + 66 NuclAT_17 - -
- 330860..330925 + 66 NuclAT_17 - -
- 330860..330925 + 66 NuclAT_17 - -
- 330860..330925 + 66 NuclAT_19 - -
- 330860..330925 + 66 NuclAT_19 - -
- 330860..330925 + 66 NuclAT_19 - -
- 330860..330925 + 66 NuclAT_19 - -
- 330860..330925 + 66 NuclAT_21 - -
- 330860..330925 + 66 NuclAT_21 - -
- 330860..330925 + 66 NuclAT_21 - -
- 330860..330925 + 66 NuclAT_21 - -
- 330860..330925 + 66 NuclAT_23 - -
- 330860..330925 + 66 NuclAT_23 - -
- 330860..330925 + 66 NuclAT_23 - -
- 330860..330925 + 66 NuclAT_23 - -
QE11421_RS01690 331239..331346 - 108 WP_000170965.1 type I toxin-antitoxin system toxin Ldr family protein -
- 331394..331457 + 64 NuclAT_26 - -
- 331394..331457 + 64 NuclAT_26 - -
- 331394..331457 + 64 NuclAT_26 - -
- 331394..331457 + 64 NuclAT_26 - -
- 331394..331457 + 64 NuclAT_29 - -
- 331394..331457 + 64 NuclAT_29 - -
- 331394..331457 + 64 NuclAT_29 - -
- 331394..331457 + 64 NuclAT_29 - -
- 331394..331457 + 64 NuclAT_32 - -
- 331394..331457 + 64 NuclAT_32 - -
- 331394..331457 + 64 NuclAT_32 - -
- 331394..331457 + 64 NuclAT_32 - -
- 331394..331457 + 64 NuclAT_35 - -
- 331394..331457 + 64 NuclAT_35 - -
- 331394..331457 + 64 NuclAT_35 - -
- 331394..331457 + 64 NuclAT_35 - -
- 331394..331457 + 64 NuclAT_39 - -
- 331394..331457 + 64 NuclAT_39 - -
- 331394..331457 + 64 NuclAT_39 - -
- 331394..331457 + 64 NuclAT_39 - -
- 331394..331457 + 64 NuclAT_42 - -
- 331394..331457 + 64 NuclAT_42 - -
- 331394..331457 + 64 NuclAT_42 - -
- 331394..331457 + 64 NuclAT_42 - -
- 331394..331461 + 68 NuclAT_45 - -
- 331394..331461 + 68 NuclAT_45 - -
- 331394..331461 + 68 NuclAT_45 - -
- 331394..331461 + 68 NuclAT_45 - -
QE11421_RS01695 331751..332851 - 1101 WP_001295620.1 sodium-potassium/proton antiporter ChaA -
QE11421_RS01700 333121..333351 + 231 WP_001146444.1 putative cation transport regulator ChaB -
QE11421_RS01705 333509..334204 + 696 WP_001297117.1 glutathione-specific gamma-glutamylcyclotransferase -
QE11421_RS01710 334248..334601 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3961.74 Da        Isoelectric Point: 9.1413

>T150054 WP_000170951.1 NZ_CP048821:c330276-330169 [Escherichia coli]
MTLAQFAMIFWDDLAAPILAGIITAAIVGWWRNRK

Download         Length: 108 bp

>T150054 NZ_CP064383:4855528-4855701 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 67 bp

>AT150054 NZ_CP048821:330324-330390 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PKK3

Antitoxin

Download structure file

References