Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2824883..2825465 Replicon chromosome
Accession NZ_CP048812
Organism Halomonas socia strain CKY01

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag G3568_RS13360 Protein ID WP_163502588.1
Coordinates 2825184..2825465 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G3568_RS13355 Protein ID WP_163502587.1
Coordinates 2824883..2825173 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3568_RS13330 2821126..2822100 + 975 WP_205601028.1 sel1 repeat family protein -
G3568_RS13335 2822163..2823101 + 939 WP_163504290.1 sel1 repeat family protein -
G3568_RS13340 2823128..2824102 + 975 WP_163502585.1 sel1 repeat family protein -
G3568_RS13345 2824168..2824593 + 426 WP_163502586.1 hypothetical protein -
G3568_RS13350 2824594..2824857 + 264 WP_205600822.1 hypothetical protein -
G3568_RS13355 2824883..2825173 - 291 WP_163502587.1 HigA family addiction module antidote protein Antitoxin
G3568_RS13360 2825184..2825465 - 282 WP_163502588.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G3568_RS13365 2825896..2826108 - 213 Protein_2624 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
G3568_RS13370 2826202..2826960 - 759 WP_163502589.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
G3568_RS13375 2827380..2827955 + 576 WP_176475829.1 aminodeoxychorismate/anthranilate synthase component II -
G3568_RS13380 2827969..2828988 + 1020 WP_163502590.1 anthranilate phosphoribosyltransferase -
G3568_RS13385 2829025..2829831 + 807 WP_163502591.1 indole-3-glycerol phosphate synthase TrpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2822220..2870564 48344


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(16-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10771.36 Da        Isoelectric Point: 9.5803

>T150040 WP_163502588.1 NZ_CP048812:c2825465-2825184 [Halomonas socia]
MIKSIKDKEAGCIVRGKVSRKLPHDMQRSALKKLRQLDAAANLDDLRILPGNRLEALKGDRNGQYSIRINDQWRLCFRFE
DGNAYDVEIVDYH

Download         Length: 282 bp

>T150040 NZ_CP064383:c837069-836782 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10811.26 Da        Isoelectric Point: 8.5148

>AT150040 WP_163502587.1 NZ_CP048812:c2825173-2824883 [Halomonas socia]
MTTQQLPNIHPGEILLEDFIEPMGLTKNALANAISVPATRIGEITRGARAITADTDLRLSRYFGTSEGYWLRLQNAYDLE
QARRARRYDAIRPHAA

Download         Length: 291 bp

>AT150040 NZ_CP064383:c837260-837069 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References