Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 81640..82314 | Replicon | plasmid pEGKP4.1 |
| Accession | NZ_CP048801 | ||
| Organism | Klebsiella pneumoniae strain EGKP4 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5Q9LMS5 |
| Locus tag | G4I41_RS26715 | Protein ID | WP_032720638.1 |
| Coordinates | 81640..81963 (+) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | G4I41_RS26720 | Protein ID | WP_032720637.1 |
| Coordinates | 82012..82314 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G4I41_RS26680 (G4I41_27125) | 76916..77281 | - | 366 | WP_001294656.1 | mercuric ion transporter MerT | - |
| G4I41_RS26685 (G4I41_27130) | 77353..77808 | + | 456 | WP_001166628.1 | Hg(II)-responsive transcriptional regulator | - |
| G4I41_RS26690 (G4I41_27135) | 77842..78390 | + | 549 | Protein_87 | SOS response-associated peptidase family protein | - |
| G4I41_RS26695 (G4I41_27140) | 78786..79483 | + | 698 | WP_223367361.1 | IS1 family transposase | - |
| G4I41_RS26700 (G4I41_27145) | 79981..80583 | + | 603 | Protein_89 | RNA-guided endonuclease TnpB family protein | - |
| G4I41_RS26705 | 80652..81079 | - | 428 | Protein_90 | DNA-binding protein | - |
| G4I41_RS26710 (G4I41_27150) | 81057..81462 | + | 406 | Protein_91 | DUF4113 domain-containing protein | - |
| G4I41_RS26715 (G4I41_27155) | 81640..81963 | + | 324 | WP_032720638.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| G4I41_RS26720 (G4I41_27160) | 82012..82314 | + | 303 | WP_032720637.1 | NadS family protein | Antitoxin |
| G4I41_RS26725 (G4I41_27165) | 82357..82524 | - | 168 | WP_153591440.1 | hypothetical protein | - |
| G4I41_RS26730 (G4I41_27170) | 82712..82918 | - | 207 | WP_153591439.1 | hypothetical protein | - |
| G4I41_RS26735 (G4I41_27175) | 82915..83298 | - | 384 | WP_032720636.1 | hypothetical protein | - |
| G4I41_RS26740 (G4I41_27180) | 83403..83975 | - | 573 | WP_032720635.1 | GNAT family N-acetyltransferase | - |
| G4I41_RS26745 (G4I41_27185) | 83977..84789 | - | 813 | WP_223203129.1 | TSUP family transporter | - |
| G4I41_RS26750 (G4I41_27190) | 84801..85721 | - | 921 | WP_050548604.1 | TauD/TfdA family dioxygenase | - |
| G4I41_RS26755 (G4I41_27195) | 86024..86518 | - | 495 | WP_044266755.1 | hypothetical protein | - |
| G4I41_RS26760 (G4I41_27200) | 86549..87121 | - | 573 | WP_044266753.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(A) / blaSHV-12 / blaOXA-10 / qacE / sul1 | - | 1..192902 | 192902 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12372.29 Da Isoelectric Point: 9.6240
>T150026 WP_032720638.1 NZ_CP048801:81640-81963 [Klebsiella pneumoniae]
MNYLEFVETSAFSGLRKELMDDDEFRELQTYLLEAHDRGDTISHTGGCRKIRWGRPGMGKRGGVRVIYYVRLASGRLYLL
LIYPKNAKDELSEKEKAVMKALTQQLK
MNYLEFVETSAFSGLRKELMDDDEFRELQTYLLEAHDRGDTISHTGGCRKIRWGRPGMGKRGGVRVIYYVRLASGRLYLL
LIYPKNAKDELSEKEKAVMKALTQQLK
Download Length: 324 bp
>T150026 NZ_CP064376:2827831-2828109 [Shigella sonnei]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11211.12 Da Isoelectric Point: 7.3611
>AT150026 WP_032720637.1 NZ_CP048801:82012-82314 [Klebsiella pneumoniae]
MEKKLFDALISSMEEMVAIENGQIQPAAEQVHRHTLPDVKAIRKHAGMKQAEFAEVVGASVDLVRSWEQQRRVPSGIALK
MLCLIEREPALINTLRGIHV
MEKKLFDALISSMEEMVAIENGQIQPAAEQVHRHTLPDVKAIRKHAGMKQAEFAEVVGASVDLVRSWEQQRRVPSGIALK
MLCLIEREPALINTLRGIHV
Download Length: 303 bp
>AT150026 NZ_CP064376:2827568-2827828 [Shigella sonnei]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCTGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCTGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|