Detailed information of TA system TA150004

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 4201842..4202346
• Replicon: chromosome
• Accession: NZ_CP048796
• Organism: Providencia vermicola strain P8538

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: G3341_RS19135
• Protein ID: WP_163863389.1
• Coordinates: 4202089..4202346 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: G3341_RS19130
• Protein ID: WP_163863387.1
• Coordinates: 4201842..4202096 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G3341_RS19110	4197515..4197943	+	429	WP_163863379.1	protein tyrosine phosphatase	-
G3341_RS19115	4197977..4200055	+	2079	WP_163863383.1	polysaccharide biosynthesis tyrosine autokinase	-
G3341_RS19120	4200072..4201097	+	1026	WP_163863385.1	UDP-glucose 4-epimerase GalE	-
G3341_RS19125	4201260..4201763	+	504	WP_154624169.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
G3341_RS19130	4201842..4202096	+	255	WP_163863387.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
G3341_RS19135	4202089..4202346	+	258	WP_163863389.1	Txe/YoeB family addiction module toxin	Toxin
G3341_RS19140	4202456..4203277	-	822	WP_154624171.1	serine O-acetyltransferase	-
G3341_RS19145	4203303..4204331	-	1029	WP_154624172.1	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	-
G3341_RS19150	4204340..4204807	-	468	WP_154624173.1	protein-export chaperone SecB	-
G3341_RS19155	4204927..4205364	-	438	WP_154624174.1	rhodanese-like domain-containing protein	-
G3341_RS19160	4205861..4207153	+	1293	WP_163863391.1	murein hydrolase activator EnvC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10250.77 Da
• Isoelectric Point: 9.3447

>T150004 WP_163863389.1 NZ_CP048796:4202089-4202346 [Providencia vermicola]
MSRFLIWTDQGWEGYLYRQIQDKKTLKRINKLIDETKRTPFYGIGKPEPLKENLAGFWSRRIDETNRLIYSIDDEGLTII
ACRYY

Nucleotide

• Length: 258 bp

>T150004 NZ_CP064374:c550007-549906 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9502.75 Da
• Isoelectric Point: 5.6863

>AT150004 WP_163863387.1 NZ_CP048796:4201842-4202096 [Providencia vermicola]
MKTISFSEARNNLKSVLDRVVDDTDTTIITPRDSEDAGVMSLEYYNSLMETVYLLHSPANAEHLNKSIAQFKAGKVKKRE
LINE

Nucleotide

• Length: 255 bp

>AT150004 NZ_CP064374:549782-549961 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA