Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1802974..1803706 Replicon chromosome
Accession NZ_CP048792
Organism Pasteurella multocida strain VP161

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PmVP161_RS08275 Protein ID WP_061406326.1
Coordinates 1802974..1803300 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PmVP161_RS08280 Protein ID WP_005757699.1
Coordinates 1803380..1803706 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PmVP161_RS08250 1798291..1798977 + 687 WP_061406323.1 hypothetical protein -
PmVP161_RS08255 1799031..1800560 - 1530 WP_061406324.1 YifB family Mg chelatase-like AAA ATPase -
PmVP161_RS08260 1800669..1801286 - 618 WP_005724253.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
PmVP161_RS08265 1801397..1802266 + 870 WP_061406325.1 VirK/YbjX family protein -
PmVP161_RS08270 1802340..1802816 - 477 WP_042742721.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PmVP161_RS08275 1802974..1803300 + 327 WP_061406326.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PmVP161_RS08280 1803380..1803706 + 327 WP_005757699.1 HigA family addiction module antidote protein Antitoxin
PmVP161_RS08285 1803761..1805281 - 1521 WP_061406327.1 DUF560 domain-containing protein -
PmVP161_RS08290 1805340..1805930 - 591 WP_061406438.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
PmVP161_RS08295 1805993..1807003 - 1011 WP_061406328.1 hypothetical protein -
PmVP161_RS08300 1807239..1808270 - 1032 WP_061406329.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12923.75 Da        Isoelectric Point: 9.6705

>T149999 WP_061406326.1 NZ_CP048792:1802974-1803300 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSQPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

>T149999 NZ_CP064371:12272-12577 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACAGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT149999 WP_005757699.1 NZ_CP048792:1803380-1803706 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp

>AT149999 NZ_CP064371:12052-12270 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGTCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References