Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3665230..3665814 Replicon chromosome
Accession NZ_CP048788
Organism Roseobacter ponti strain DSM 106830

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G3256_RS17655 Protein ID WP_169642071.1
Coordinates 3665230..3665511 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G3256_RS17660 Protein ID WP_169642072.1
Coordinates 3665524..3665814 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3256_RS17625 3660444..3661133 - 690 WP_169642066.1 DUF2306 domain-containing protein -
G3256_RS17630 3661310..3662416 + 1107 WP_169642067.1 3-isopropylmalate dehydrogenase -
G3256_RS17640 3662635..3663084 - 450 WP_169642068.1 hypothetical protein -
G3256_RS17645 3663276..3664355 - 1080 WP_169642069.1 tyrosine-type recombinase/integrase -
G3256_RS17650 3664349..3665029 + 681 WP_169642070.1 ImmA/IrrE family metallo-endopeptidase -
G3256_RS17655 3665230..3665511 + 282 WP_169642071.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G3256_RS17660 3665524..3665814 + 291 WP_169642072.1 HigA family addiction module antidote protein Antitoxin
G3256_RS17665 3665847..3666917 - 1071 WP_169642073.1 hypothetical protein -
G3256_RS17670 3667080..3667379 - 300 WP_169642074.1 hypothetical protein -
G3256_RS17675 3667557..3667820 - 264 Protein_3486 hypothetical protein -
G3256_RS17685 3668642..3669685 + 1044 WP_169642075.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(18-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10258.78 Da        Isoelectric Point: 9.6879

>T149997 WP_169642071.1 NZ_CP048788:3665230-3665511 [Roseobacter ponti]
MIQSTKGKLAANAVKGKYGKGFPGDLVKRTRAMLSALDAAVVVEDLRFPPGNHLEELKGDRAGQHSVRINGQWRICFVWT
PNGPTEVEIVDYH

Download         Length: 282 bp

>T149997 NZ_CP064369:c10133-9819 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGAGATTTACAACGCCTCCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGCCGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CATTTCTGCCGCTGGAATATCAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCGGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10700.44 Da        Isoelectric Point: 5.0492

>AT149997 WP_169642072.1 NZ_CP048788:3665524-3665814 [Roseobacter ponti]
MSLLENPMHPGEVLKELYLDPLDMGAIAFARRLGVPRTRIERLIKGTTGITPDTALRFARVFNTTPAYWVNLQTNYDMAL
AAKEIDVSDIEPLIAA

Download         Length: 291 bp

>AT149997 NZ_CP064369:c10399-10121 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AAGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCAGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References