Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4250484..4251136 Replicon chromosome
Accession NZ_CP048784
Organism Serratia liquefaciens strain S1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag F0336_RS20125 Protein ID WP_149573995.1
Coordinates 4250484..4250828 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F0336_RS20130 Protein ID WP_149573996.1
Coordinates 4250834..4251136 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0336_RS20110 4247711..4248730 + 1020 WP_149573993.1 HTH-type transcriptional regulator GalR -
F0336_RS20115 4248727..4249182 - 456 WP_149573994.1 GNAT family N-acetyltransferase -
F0336_RS20120 4249334..4250344 + 1011 WP_046372749.1 LacI family DNA-binding transcriptional regulator -
F0336_RS20125 4250484..4250828 + 345 WP_149573995.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0336_RS20130 4250834..4251136 + 303 WP_149573996.1 helix-turn-helix transcriptional regulator Antitoxin
F0336_RS20135 4251167..4252429 - 1263 WP_149573997.1 diaminopimelate decarboxylase -
F0336_RS20140 4252556..4253479 + 924 WP_046372747.1 LysR family transcriptional regulator -
F0336_RS20145 4253469..4254623 - 1155 WP_046372746.1 MFS transporter -
F0336_RS20150 4254941..4255849 - 909 WP_020828415.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13536.65 Da        Isoelectric Point: 10.8313

>T149988 WP_149573995.1 NZ_CP048784:4250484-4250828 [Serratia liquefaciens]
MWQIVTVERFDSWFLSLNNDQQKSVLVGIFKLQEFGPLLARPHADTLNHKNQIQHLKELRIQHRGRPFRIFFAFDPQRQA
VLLCGGDKTGNKRFYQQMLPIAIREFSHYLATQR

Download         Length: 345 bp

>T149988 NZ_CP064368:c2495424-2494891 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTATTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11142.01 Da        Isoelectric Point: 8.6004

>AT149988 WP_149573996.1 NZ_CP048784:4250834-4251136 [Serratia liquefaciens]
MAKPLSDLIDKLDPTVVEAAQQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLEVQLPNGQHRRMTL

Download         Length: 303 bp

>AT149988 NZ_CP064368:c2495701-2495435 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References