Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4766105..4766707 Replicon chromosome
Accession NZ_CP048736
Organism Enterobacter sp. T2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G0034_RS22800 Protein ID WP_047624626.1
Coordinates 4766396..4766707 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B2XUJ3
Locus tag G0034_RS22795 Protein ID WP_032635182.1
Coordinates 4766105..4766395 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0034_RS22780 (4763603) 4763603..4764505 + 903 WP_008501831.1 formate dehydrogenase subunit beta -
G0034_RS22785 (4764502) 4764502..4765137 + 636 WP_179121281.1 formate dehydrogenase cytochrome b556 subunit -
G0034_RS22790 (4765134) 4765134..4766063 + 930 WP_047343709.1 formate dehydrogenase accessory protein FdhE -
G0034_RS22795 (4766105) 4766105..4766395 - 291 WP_032635182.1 NadS family protein Antitoxin
G0034_RS22800 (4766396) 4766396..4766707 - 312 WP_047624626.1 hypothetical protein Toxin
G0034_RS22805 (4766936) 4766936..4767856 + 921 WP_179121282.1 alpha/beta hydrolase -
G0034_RS22810 (4767865) 4767865..4768806 - 942 WP_023336483.1 fatty acid biosynthesis protein FabY -
G0034_RS22815 (4768851) 4768851..4769288 - 438 WP_014885747.1 D-aminoacyl-tRNA deacylase -
G0034_RS22820 (4769285) 4769285..4770166 - 882 WP_014885748.1 virulence factor BrkB family protein -
G0034_RS22825 (4770160) 4770160..4770759 - 600 WP_045268693.1 glucose-1-phosphatase -
G0034_RS22830 (4770879) 4770879..4771679 - 801 WP_014885750.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12215.24 Da        Isoelectric Point: 10.2130

>T149946 WP_047624626.1 NZ_CP048736:c4766707-4766396 [Enterobacter sp. T2]
MLFIETDIFTEDVKTLLDDDEYHKLQVFLVTQPNNGDLIQNTGGLRKIRWFSGSKGKRGGVRVIYFHRTREFEIRLLLIY
RKGIKDDLSAKEKAILKKMIERW

Download         Length: 312 bp

>T149946 NZ_CP064352:761247-761349 [Klebsiella pneumoniae subsp. pneumoniae ATCC 43816]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10703.22 Da        Isoelectric Point: 10.5888

>AT149946 WP_032635182.1 NZ_CP048736:c4766395-4766105 [Enterobacter sp. T2]
MDKALFERLTQSIAQMNEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT149946 NZ_CP064352:c761356-761211 [Klebsiella pneumoniae subsp. pneumoniae ATCC 43816]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A8B2XUJ3

References