Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1160351..1161000 Replicon chromosome
Accession NZ_CP048736
Organism Enterobacter sp. T2

Toxin (Protein)


Gene name higB Uniprot ID A0A2J0PLQ3
Locus tag G0034_RS05450 Protein ID WP_014882864.1
Coordinates 1160638..1161000 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2W0GCS7
Locus tag G0034_RS05445 Protein ID WP_014882863.1
Coordinates 1160351..1160650 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0034_RS05435 (1156776) 1156776..1158749 + 1974 WP_179120588.1 PhoX family phosphatase -
G0034_RS05440 (1158852) 1158852..1160240 + 1389 WP_179120589.1 phenylalanine transporter -
G0034_RS05445 (1160351) 1160351..1160650 - 300 WP_014882863.1 helix-turn-helix transcriptional regulator Antitoxin
G0034_RS05450 (1160638) 1160638..1161000 - 363 WP_014882864.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G0034_RS05455 (1161206) 1161206..1162441 + 1236 WP_179120590.1 MFS transporter -
G0034_RS05460 (1162457) 1162457..1163482 + 1026 WP_063666829.1 sugar phosphate isomerase/epimerase family protein -
G0034_RS05465 (1163475) 1163475..1164617 + 1143 WP_179120591.1 Gfo/Idh/MocA family oxidoreductase -
G0034_RS05470 (1164693) 1164693..1165664 + 972 WP_045281665.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13952.92 Da        Isoelectric Point: 6.7114

>T149935 WP_014882864.1 NZ_CP048736:c1161000-1160638 [Enterobacter sp. T2]
MWNVETTDRFDQWYFEQTTALKEDVLAMMHILAEFGPTLGRPYVDTVKASAYANMKELRIQHAGNPIRAFFAFDPDRKAI
VLCAGNKTGCNQKRFYNEMITLADVEYSRHLADKEAIWQR

Download         Length: 363 bp

>T149935 NZ_CP064351:c466286-465996 [Vibrio cholerae C6706]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10860.61 Da        Isoelectric Point: 9.8627

>AT149935 WP_014882863.1 NZ_CP048736:c1160650-1160351 [Enterobacter sp. T2]
MATLKELMAQQSAESQERIAAKVDVIRRIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPGNDPRLSTLKRYVSALG
GEMSIDVTLPNGKRIAFQI

Download         Length: 300 bp

>AT149935 NZ_CP064351:c466524-466276 [Vibrio cholerae C6706]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PLQ3

Antitoxin

Source ID Structure
AlphaFold DB A0A2W0GCS7

References