Detailed information of TA system TA149931

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 64613..65171
• Replicon: chromosome
• Accession: NZ_CP048736
• Organism: Enterobacter sp. T2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: G0034_RS00340
• Protein ID: WP_269836741.1
• Coordinates: 64932..65171 (-)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: G0034_RS00335
• Protein ID: WP_032635284.1
• Coordinates: 64613..64912 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0034_RS00305 (60028)	60028..60987	-	960	WP_023336511.1	DUF523 and DUF1722 domain-containing protein	-
G0034_RS00310 (61090)	61090..61500	-	411	WP_014881954.1	hydroxyisourate hydrolase	-
G0034_RS00315 (61600)	61600..62325	-	726	WP_014881955.1	MerR family transcriptional regulator	-
G0034_RS00320 (62443)	62443..62967	+	525	WP_014881956.1	lipocalin family protein	-
G0034_RS00325 (63046)	63046..64044	+	999	WP_179120407.1	class I SAM-dependent methyltransferase	-
G0034_RS00330 (64146)	64146..64583	+	438	WP_045281332.1	acetyltransferase	-
G0034_RS00335 (64613)	64613..64912	-	300	WP_032635284.1	XRE family transcriptional regulator	Antitoxin
G0034_RS00340 (64932)	64932..65171	-	240	WP_269836741.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G0034_RS23230 (65420)	65420..65614	-	195	Protein_67	hydroxyacid dehydrogenase	-
G0034_RS00345 (65719)	65719..66060	-	342	WP_032644385.1	SymE family type I addiction module toxin	-
G0034_RS00350 (66189)	66189..66362	+	174	WP_112780025.1	YlcI/YnfO family protein	-
G0034_RS00355 (66637)	66637..66849	-	213	WP_179120408.1	hypothetical protein	-
G0034_RS00360 (67020)	67020..68000	-	981	WP_000019473.1	IS5-like element ISKpn26 family transposase	-
G0034_RS00365 (68041)	68041..68301	-	261	WP_179120409.1	hypothetical protein	-
G0034_RS00370 (68301)	68301..69188	-	888	WP_286079226.1	DUF3800 domain-containing protein	-
G0034_RS00375 (69170)	69170..70150	-	981	WP_000019473.1	IS5-like element ISKpn26 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-72)

Antitoxin

• HigA2-like, helix-turn-helix domain (13-88)

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 9040.64 Da
• Isoelectric Point: 7.0054

>T149931 WP_269836741.1 NZ_CP048736:c65171-64932 [Enterobacter sp. T2]
MWTVLFGKVFELWLPEQEEGLQEKVLAAMLNLQNYGPHLPYADTVKGSQYKNMKELGIQYAGRPIRALFALQMMNLPGI

Nucleotide

• Length: 240 bp

>T149931 NZ_CP064351:c410220-409942 [Vibrio cholerae C6706]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11160.04 Da
• Isoelectric Point: 6.9842

>AT149931 WP_032635284.1 NZ_CP048736:c64912-64613 [Enterobacter sp. T2]
VKTLNELIASRSPESQQRIKEMAEEMILETGLQLLREELRLSQKNVAELMGVSQPAVTQIEQRGNELKIATLKRYIEAMG
GKLCIDVELPTGKRVAFHI

Nucleotide

• Length: 300 bp

>AT149931 NZ_CP064351:c410501-410217 [Vibrio cholerae C6706]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA